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Sci. Pharm. 2009, 77(Posters (PO)), 201; https://doi.org/10.3797/scipharm.oephg.21.PO-02 (registering DOI)
QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
Department of Drug and Natural Product Synthesis, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract P-Glycoprotein (P-gp) is a member of the ABC (ATP binding cassette) super-family of transport proteins, which in addition to their physiological role in tissue protection, actively extrude a large variety of therapeutically administered drugs from the malignant cells and thus are responsible for multiple drug resistance (MDR) in cancer patients . Since the discovery of P-gp more than 30 years ago many studies have shown that MDR can be reversed by the use of inhibitors, often denoted as MDR modulators.
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JABEEN, I.; PLAGENS, B.; HOLZER, W.; ECKER, G.F. QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein. Sci. Pharm. 2009, 77, 201.
JABEEN I, PLAGENS B, HOLZER W, ECKER GF. QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein. Scientia Pharmaceutica. 2009; 77(Posters (PO)):201.
JABEEN, I.; PLAGENS, B.; HOLZER, W.; ECKER, G. F. 2009. "QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein." Sci. Pharm. 77, Posters (PO): 201.
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