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Sci. Pharm. 2009, 77(Posters (PO)), 201; doi:10.3797/scipharm.oephg.21.PO-02 (registering DOI)

QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein

1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
2
Department of Drug and Natural Product Synthesis, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

P-Glycoprotein (P-gp) is a member of the ABC (ATP binding cassette) super-family of transport proteins, which in addition to their physiological role in tissue protection, actively extrude a large variety of therapeutically administered drugs from the malignant cells and thus are responsible for multiple drug resistance (MDR) in cancer patients [1]. Since the discovery of P-gp more than 30 years ago many studies have shown that MDR can be reversed by the use of inhibitors, often denoted as MDR modulators.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

JABEEN, I.; PLAGENS, B.; HOLZER, W.; ECKER, G.F. QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein. Sci. Pharm. 2009, 77, 201.

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