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Sci. Pharm. 2009, 77(Short Lectures (SL)), 190; doi:10.3797/scipharm.oephg.21.SL-23 (registering DOI)

Differences in the Glycocalyx of 5637 and SV-HUC-1 Cells and their Impact on Lectin Targeting

1
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
2
School of Pharmaceutical Sciences Geneva-Lausanne, University of Geneva, Quai Ernest-Ansermet 30, CH-1211, Geneva, Switzerland
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

Background: Bladder cancer is one of the most common malignancies. Advances have been made in diagnosis, therapy, and surveillance resulting in increasing survival rates of patients, but the search for more effective therapies is imperative to be continued. Among others, lectin-mediated targeting might be a promising concept. Thus, the potential of fluorescein-labeled plant lectins was investigated using 5637 cells as a model for human urinary carcinoma [1] and SV-HUC-1 cells as a model for non-tumorigenic human uroepithelial cells.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

PLATTNER, V.E.; GABOR, F.; BORCHARD, G.; WIRTH, M. Differences in the Glycocalyx of 5637 and SV-HUC-1 Cells and their Impact on Lectin Targeting. Sci. Pharm. 2009, 77, 190.

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