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Sci. Pharm. 2009, 77(Short Lectures (SL)), 187; doi:10.3797/scipharm.oephg.21.SL-20 (registering DOI)

Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification

1
Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
2
Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11, A-1121, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

The ABC-transporter ABCB1 (P-glycoprotein) is a drug efflux pump playing an important role in the transport route of drugs through tissue barriers, protection against xenobiotics, and in cancer drug resistance. Due to this, ABCB1 is notorious for limiting bioavailability of various chemical and functional unrelated drugs.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

DEMEL, M.A.; KRÄMER, O.; ETTMAYER, P.; HAAKSMA, E.E.J.; ECKER, G.F. Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification. Sci. Pharm. 2009, 77, 187.

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