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Sci. Pharm. 2009, 77(Short Lectures (SL)), 186; doi:10.3797/scipharm.oephg.21.SL-19 (registering DOI)
Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells
PharmaCon GmbH, Riglergasse 4/5, 1180, Vienna, Austria
Biopredic International, 8-18 rue Jean Pecker, 35000, Rennes, France
Dep. for Cell Imaging and Ultrastructure Res., University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Dep. of Pharm. Techn. and Biopharm., University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Dep. of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Note: In lieu of an abstract, this is an excerpt from the first page.
The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation . Until now, no standard in vitro
model of the BBB is available. In this contribution a novel BBB in vitro
model based on primary rat brain microvasculature endothelial cells (RBMEC) and primary rat glial cells (RGC) is introduced. The cells were isolated from Wistar rats and were provided by the company Biopredic Int. RBMEC were co-cultured with RGC in a 12-well Transwell system. The development of the barrier was monitored by the measurement of the transendothelial electrical resistance (TEER).[...]
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NEUHAUS, W.; SUBILEAU, E.; CHESNE, C.; GRUBER, D.; TÖGEL, S.; KLEPAL, W.; NOE, C.R. Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells. Sci. Pharm. 2009, 77, 186.
NEUHAUS W, SUBILEAU E, CHESNE C, GRUBER D, TÖGEL S, KLEPAL W, NOE CR. Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):186.
NEUHAUS, W.; SUBILEAU, E.; CHESNE, C.; GRUBER, D.; TÖGEL, S.; KLEPAL, W.; NOE, C. R. 2009. "Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells." Sci. Pharm. 77, Short Lectures (SL): 186.
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