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Sci. Pharm. 2009, 77(Short Lectures (SL)), 186; doi:10.3797/scipharm.oephg.21.SL-19 (registering DOI)

Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells

1
PharmaCon GmbH, Riglergasse 4/5, 1180, Vienna, Austria
2
Biopredic International, 8-18 rue Jean Pecker, 35000, Rennes, France
3
Dep. for Cell Imaging and Ultrastructure Res., University of Vienna, Althanstraße 14, 1090, Vienna, Austria
4
Dep. of Pharm. Techn. and Biopharm., University of Vienna, Althanstraße 14, 1090, Vienna, Austria
5
Dep. of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Excerpt

The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation [1]. Until now, no standard in vitro model of the BBB is available. In this contribution a novel BBB in vitro model based on primary rat brain microvasculature endothelial cells (RBMEC) and primary rat glial cells (RGC) is introduced. The cells were isolated from Wistar rats and were provided by the company Biopredic Int. RBMEC were co-cultured with RGC in a 12-well Transwell system. The development of the barrier was monitored by the measurement of the transendothelial electrical resistance (TEER).[...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

NEUHAUS, W.; SUBILEAU, E.; CHESNE, C.; GRUBER, D.; TÖGEL, S.; KLEPAL, W.; NOE, C.R. Evaluation of a Blood-Brain Barrier in vitro Model Based on Primary Rat Cells. Sci. Pharm. 2009, 77, 186.

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