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Sci. Pharm. 2009, 77(Short Lectures (SL)), 178; doi:10.3797/scipharm.oephg.21.SL-11 (registering DOI)

An Acoustically-Driven Biochip: Particle-Cell In-teractions Under Physiological Flow Conditions

1
Dept. of Pharm. Technology& Biopharmaceutics, University of Vienna, Althanstr. 14, 1090 Vienna, Austria
2
Biological Physics Group, University Augsburg, Universitätsstr. 1, 86159, Augsburg, Germany
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

Introduction: The interaction of particulate drug carriers with cells has generally been assessed in stationary microplate assays. These setups fail to reflect the flow conditions in vivo which generate substantial hydrodynamic drag forces [1]. In order to address this shortcoming, a microfluidic biochip with the capability of imitating a wide range of shear rates and pulsation modes has been developed. This device, which is based on an incorporated surface acoustic wave pump, was used to study the interaction of targeted microparticles with epithelial cells under flow conditions.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

FILLAFER, C.; RATZINGER, G.; NEUMANN, J.; DISSAUER, S.; WIRTH, M.; GABOR, F.; SCHNEIDER, M. An Acoustically-Driven Biochip: Particle-Cell In-teractions Under Physiological Flow Conditions. Sci. Pharm. 2009, 77, 178.

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