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Sci. Pharm. 2009, 77(3), 639-650; doi:10.3797/scipharm.0902-05

Development of a w/o/w-Emulsion Containing N-Acetylcysteine for Cosmetic Use

Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Universite-34116, İstanbul, Turkey
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Received: 6 February 2009 / Accepted: 4 June 2009 / Published: 4 June 2009
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Abstract

N-Acetylcysteine was known to be used as a mucolytic agent having significant antioxidant activity. It has been reported to be used to alleviate or improve various cosmetic conditions and dermatological disorders including changes or damage to skin associated with intrinsic or extrinsic aging recently. However many benefits regarding to its antioxidant effects were reported, its probable potential moisturizing effects have not been stated yet. Since N-acetylcysteine has similar effects as vitamin C, it might be assumed that it could also increase skin hydration by its antioxidant capacity. The aim of this work was to investigate the feasibility of a topical delivery system as a multiple emulsion containing N-acteylcysteine and compare the moisturizing potential of this formulation with a base multiple emulsion and vitamin E which was chosen as a popular moisturizer.
Keywords: N-Acetylcysteine; Multiple emulsion; Moisturization; Vitamin E; Topical delivery N-Acetylcysteine; Multiple emulsion; Moisturization; Vitamin E; Topical delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

YENER, G.; İncegülKE, T. Development of a w/o/w-Emulsion Containing N-Acetylcysteine for Cosmetic Use. Sci. Pharm. 2009, 77, 639-650.

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