Design and Development of a Self Correcting Monolithic Gastroretentive Tablet of Baclofen
AbstractThe present investigation describes the design and development of selfcorrecting monolithic Gastroretentive system of baclofen. Tablets were prepared by direct compression method. Optimization was carried out using simplex lattice design. Drug released at 2h, 4h, 8h, and floating lag time were considered as response variables related to percentages of diluent (MCC), Polyethylene oxide (PEO) and sodium bicarbonate. Tablets were evaluated for in-vitro buoyancy, in-vitro drug release, swelling index and ex-vivo bioadhesion studies. The similarity factor (f2) was used as a base to compare dissolution profiles. Drug release data was fitted into different kinetic models. The floating lag time and floating time were found to be 2min and 12h respectively. Increasing trend in bioadhesive strength was observed with an increase in the amount of PEO. The experimental values of Q2, Q4 and Q8 for check point batch were found to be 30.8%, 44.1% and 69.9% respectively. Similarity factor (f2) for check point batch was 78.08. Kinetics of drug release from tablet followed Korsmeyer–Peppas model by anamolous non-fickian diffusion. It was concluded that gastroretentive tablet of baclofen can be prepared via floating and bioadhesion mechanism to increase residence time of drug in stomach and there by increases absorption.
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JIVANI, R.R.; PATEL, C.N.; JIVANI, N.P. Design and Development of a Self Correcting Monolithic Gastroretentive Tablet of Baclofen. Sci. Pharm. 2009, 77, 651-668.
JIVANI RR, PATEL CN, JIVANI NP. Design and Development of a Self Correcting Monolithic Gastroretentive Tablet of Baclofen. Scientia Pharmaceutica. 2009; 77(3):651-668.Chicago/Turabian Style
JIVANI, Rishad R.; PATEL, Chhagan N.; JIVANI, Nuruddin P. 2009. "Design and Development of a Self Correcting Monolithic Gastroretentive Tablet of Baclofen." Sci. Pharm. 77, no. 3: 651-668.