Next Article in Journal
Formulation and In Vitro Evaluation of Sunflower Oil Entrapped within Buoyant Beads of Furosemide
Previous Article in Journal
Development of a w/o/w-Emulsion Containing N-Acetylcysteine for Cosmetic Use
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2009, 77(3), 651-668; doi:10.3797/scipharm.0905-11

Design and Development of a Self Correcting Monolithic Gastroretentive Tablet of Baclofen

1
Smt. R.B.Patel Mahila Pharmacy College, Kailash nagar, Dist: Rajkot, Atkot-360040, Gujarat, India
2
Shari Sarvajanik Pharmacy College, Mehsana-384001, Gujarat, India
*
Author to whom correspondence should be addressed.
Received: 17 May 2009 / Accepted: 21 July 2009 / Published: 24 July 2009
Download PDF [360 KB, uploaded 21 December 2016]

Abstract

The present investigation describes the design and development of selfcorrecting monolithic Gastroretentive system of baclofen. Tablets were prepared by direct compression method. Optimization was carried out using simplex lattice design. Drug released at 2h, 4h, 8h, and floating lag time were considered as response variables related to percentages of diluent (MCC), Polyethylene oxide (PEO) and sodium bicarbonate. Tablets were evaluated for in-vitro buoyancy, in-vitro drug release, swelling index and ex-vivo bioadhesion studies. The similarity factor (f2) was used as a base to compare dissolution profiles. Drug release data was fitted into different kinetic models. The floating lag time and floating time were found to be 2min and 12h respectively. Increasing trend in bioadhesive strength was observed with an increase in the amount of PEO. The experimental values of Q2, Q4 and Q8 for check point batch were found to be 30.8%, 44.1% and 69.9% respectively. Similarity factor (f2) for check point batch was 78.08. Kinetics of drug release from tablet followed Korsmeyer–Peppas model by anamolous non-fickian diffusion. It was concluded that gastroretentive tablet of baclofen can be prepared via floating and bioadhesion mechanism to increase residence time of drug in stomach and there by increases absorption.
Keywords: Baclofen; Gastro retentive drug delivery system; Simplex lattice design; Polyethylene oxide (PEO) Baclofen; Gastro retentive drug delivery system; Simplex lattice design; Polyethylene oxide (PEO)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

JIVANI, R.R.; PATEL, C.N.; JIVANI, N.P. Design and Development of a Self Correcting Monolithic Gastroretentive Tablet of Baclofen. Sci. Pharm. 2009, 77, 651-668.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top