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Sci. Pharm. 2009, 77(2), 309-326; doi:10.3797/scipharm.0811-09-01

Mouth Dissolving Tablets I: An Overview of Formulation Technology

Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India
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Received: 6 November 2008 / Accepted: 5 March 2009 / Published: 6 March 2009
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Abstract

Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. MDDDS have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Therefore, these dosage forms have lured the market for a certain section of the patient population which include dysphagic, bed ridden, psychic, geriatric and paediatric patients. Several techniques have been developed in the recent past, to improve the disintegration quality of these delicate dosage forms without affecting their integrity. This article focuses on the technologies available and the advances made so far in the field of fabrication of mouth dissolving tablets. Apart from the conventional methods of fabrication, this review also provides the detailed concept of some unique patented technologies like Zydis, Lyoc, Quicksolv, Orasolv, Durasolv, Flashtab, Oraquick, Wowtab and Ziplet alongwith their advantages and limitations.
Keywords: Mouth dissolving; Fast disintegrating; Dysphagia; Lyophilization; Direct compression Mouth dissolving; Fast disintegrating; Dysphagia; Lyophilization; Direct compression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

SHUKLA, D.; CHAKRABORTY, S.; SINGH, S.; MISHRA, B. Mouth Dissolving Tablets I: An Overview of Formulation Technology. Sci. Pharm. 2009, 77, 309-326.

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