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Sci. Pharm. 2008, 76(4), 673-688; doi:10.3797/scipharm.0810-11 (registering DOI)

Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice

1
Superior Institute of Biomedical Sciences, Academic Master in Physiological Sciences, State University of Ceará, Fortaleza, Ceará, Brazil
2
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil
*
Author to whom correspondence should be addressed.
Received: 16 October 2008 / Accepted: 27 November 2008 / Published: 28 November 2008
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Abstract

This study presents the actions of risperidone (Risp) and haloperidol (Hal) on the behavioral effects elicited by ketamine (Ket) on open-field (OF), rota rod (RR) and tail suspension (TS) tests in mice. Male Swiss albino mice (25–30g) were used. Antipsychotics were administered alone (Risp: 0.1 or 0.2 mg/kg, ip; Hal: 0.1 and 0.2 mg/kg, ip) or thirty minutes before Ket (10 mg/Kg, ip). Ket increased (Ket: 63.3 ± 4.2) the locomotor activity compared to control, while neuroleptics decreased it (25.5 ± 4.2). Pretreatment with neuroleptics, in both doses, blocked hyperlocomotion caused by Ket. In RR, Ket decreased (Ket: 15 ± 4.1) the permanence time of the animals compared to control (Control: 59 ± 0.6), but this effect was not observed when neuroleptics were administered alone. Pretreatment with neuroleptics reverted the effect of Ket only in the RR. While Ket (17.3 ± 5.6) decreased the time of immobility in the tail suspension test compared to the control (80.2 ± 10.2), the pretreatment with neuroleptics reverted this mobility. The action of neuroleptics in this model made possible the blockade of the effects caused by acute administration of Ket. Thus, the mechanism of action of ketamine may involve the dopaminergic system.
Keywords: Antipsychotic drug; Ketamine; Locomotor activity; Schizophrenia Antipsychotic drug; Ketamine; Locomotor activity; Schizophrenia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

ARRUDA, M.O.V.; SOARES, P.M.; HONÓRIO, J.E.R.; LIMA, R.C.S.; CHAVES, E.M.C.; LOBATO, R.F.G.; MARTIN, A.L.A.R.; SALES, G.T.M.; CARVALHO, K.M.; ASSREUY, A.M.S.; de BRITO, E.M.; VASCONCELOS, S.M.M. Activities of the Antipsychotic Drugs Haloperidol and Risperidone on Behavioural Effects Induced by Ketamine in Mice. Sci. Pharm. 2008, 76, 673-688.

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