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Sci. Pharm. 2008, 76(4), 689-698; doi:10.3797/scipharm.0804-05 (registering DOI)

Influence of Baicalin on Alveolar Bone Resorption in Rat Experimental Periodontitis

1
Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi’an 710032, P. R. China
2
Department of Oral Histopathology, School of Stomatology, Fourth Military Medical University, Xi’an 710032, P. R. China
*
Author to whom correspondence should be addressed.
Received: 4 April 2008 / Accepted: 4 November 2008 / Published: 7 November 2008
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Abstract

Objective: In this study, the effects of baicalin – a flavonoid purified from Scutellaria baicalensis. Georgi, Scutellaria L. – on alveolar bone resorption in rat experimental periodontitis were examined. Method: 12 Sprague-Dawley rats (SD rats) were randomly divided into four groups: Group A1, A2, B and C. Except for Group C – the control group–, Group A1, A2 and B were used to establish the rat periodontitis model by repeat injection of Lipopolysaccharide (LPS). At the same time, Group A1 and A2 were injected with baicalin of different concentration. 9 days later, the maxillae were extracted and analyzed using micro computerized tomography (micro-CT), followed by histological analysis. Result: Micro-CT images showed that alveolar bone resorption was severely induced around the molar by repeat injection of LPS. Treatment with high-dose baicalin (1.0 μg / ml) clearly recovered alveolar bone resorption, meanwhile, low-dose baicalin(0.1 μg / ml) showed a similar but weaker effect. Histological examination clarified that the number of osteoclast was dose dependently decreased by baicalin treatment. Conclusion: These findings suggest that baicalin may inhibit the alveolar bone loss in periodontitis effectively.
Keywords: Baicalin; Micro-CT; Alveolar bone resorption; LPS; Rat experimental periodontitis Baicalin; Micro-CT; Alveolar bone resorption; LPS; Rat experimental periodontitis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

CHEN, Y.; WU, Z.-F.; YANG, L.-J. Influence of Baicalin on Alveolar Bone Resorption in Rat Experimental Periodontitis. Sci. Pharm. 2008, 76, 689-698.

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