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Sci. Pharm. 2008, 76(2), 269-278; doi:10.3797/scipharm.0803-14 (registering DOI)

Preservative Evaluation of Novel 2,4-Hexadienoic Acid Derivatives in Aluminium Hydroxide Gel – USP

1
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125 001, Haryana
2
Hindu College of Pharmacy, Sonepat-131001, Haryana
*
Author to whom correspondence should be addressed.
Received: 18 March 2008 / Accepted: 6 May 2008 / Published: 22 May 2008
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Abstract

The potential derivatives of sorbic acid (2,4-hexadienoic acid) from our previous study were subjected to preservative efficacy testing. Aluminium Hydroxide Gel – USP was used as a pharmaceutical product and Staphylococcus aureus MTCC 2901, Bacillus subtilis MTCC 2063, Escherichia coli MTCC 1652, Candida albicans MTCC 227 and Aspergillus niger MTCC 8189 were used as representative challenging microorganisms for antimicrobial effectiveness testing as per USP 2004. The hexadienoic acid derivative, m-nitrosorbanilide has better preservative efficacy than sorbic acid as well as the standard preservatives, methyl paraben and propyl paraben.
Keywords: Sorbic acid; m-Nitrosorbanilide; 8-Quinolinyl sorbate; Preservative; Log CFU/mL Sorbic acid; m-Nitrosorbanilide; 8-Quinolinyl sorbate; Preservative; Log CFU/mL
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

JUDGE, V.; NARASIMHAN, B.; NARANG, R.; OHLAN, R.; OHLAN, S. Preservative Evaluation of Novel 2,4-Hexadienoic Acid Derivatives in Aluminium Hydroxide Gel – USP. Sci. Pharm. 2008, 76, 269-278.

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