Next Article in Journal
Effects of Ethanol or Naltrexone after Ethanol Exposure on Plasma Levels of Hepatic Enzymes, Lipid Profile and Apolipoprotein in Rats
Previous Article in Journal
Preservative Evaluation of Novel 2,4-Hexadienoic Acid Derivatives in Aluminium Hydroxide Gel – USP
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2008, 76(2), 279-304; doi:10.3797/scipharm.0804-09 (registering DOI)

Antimicrobial Activities of some Synthesized Pyridines, Oxazines and Thiazoles from 3-Aryl-1-(2-naphthyl)prop-2-en-1-ones

1
Applied Organic Chemistry, National Research Center, Dokki, Cairo, Egypt
2
Chemistry Department, Faculty of Science, Cairo University, Egypt
3
Photochemistry Department, National Research Center, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 8 April 2008 / Accepted: 16 May 2008 / Published: 19 May 2008
Download PDF [658 KB, uploaded 28 December 2016]

Abstract

3-Aryl-1-(2-naphthyl)-prop-2-en-1-ones were reacted with ethyl cyanoacetate to produce 4-aryl-6-(2-naphthyl)-2-oxo-1,2-dihydropyridine-3-carbonitriles, which were treated with ethyl chloroacetate to give the corresponding ester. Treatment of the latter ester with hydrazine hydrate or anthranilic acid afforded hydrazides and benzoxazines. The hydrazides were reacted with benzaldehyde or phenylisothiocyanate to afford the corresponding hydrazone and thiosemicarbazide derivatives, which were cyclized with chloroacetic acid or thioglycolic acid to the corresponding thiazole derivatives. 3-Aryl-1-(2-naphthyl)-prop-2-en-1-ones were either condensed with malononitrile under different conditions to produce carbonitrile derivatives or treated with active methylene reagents to afford the substituted cyclohexene derivatives. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. Some of these compounds exhibited antimicrobial activities comparable to Ampicillin® as reference drug.
Keywords: α,β-Unsaturated ketones; Hydrazones; Thiazoles; Benzoxazine; Antimicrobials α,β-Unsaturated ketones; Hydrazones; Thiazoles; Benzoxazine; Antimicrobials
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

MOHAMED, S.F.; YOUSSEF, M.M.; AMR, A.E.-G.; KOTB, E.R. Antimicrobial Activities of some Synthesized Pyridines, Oxazines and Thiazoles from 3-Aryl-1-(2-naphthyl)prop-2-en-1-ones. Sci. Pharm. 2008, 76, 279-304.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top