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Sci. Pharm. 2008, 76(2), 203-216; doi:10.3797/scipharm.0803-16 (registering DOI)

Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats

1
Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Yercaud Main Road, Salem-636 008, Tamilnadu, India
2
Department of Pharmacology, St John's Pharmacy College, No 6. 9th Cross, 2nd Main, Vijayanagar 2nd Stage, Bangalore – 560 104, India
3
Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu-637 205, Tamilnadu, India
4
Department of Pharmacology, Bharathi College of Pharmacy, Bharathi Nagara, Mandya Dist, Karnataka, India
*
Author to whom correspondence should be addressed.
Received: 19 March 2008 / Accepted: 28 April 2008 / Published: 1 May 2008
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Abstract

Ethanol extract of Pisonia aculeata (EPA) was evaluated for hepatoprotective and antioxidant activities in rats. The plant extract (250 and 500 mg/kg, p.o.) showed a remarkable hepatoprotective and antioxidant activity against carbon tetrachloride (CCl4)-induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues. CCl4-induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST). Treatment of rats with different doses of plant extract (250 and 500 mg/kg) significantly (P<0.001) altered serum marker enzymes and antioxidant levels to near normal against CCl4-treated rats. The activity of the extract at dose of 500 mg/kg was comparable to the standard drug, silymarin (50 mg/kg, p.o.). Histopathological changes of liver sample were compared with respective control. Results indicate the hepatoprotective and antioxidant properties of P. aculeata against CCl4-induced hepatotoxicity in rats.
Keywords: Pisonia aculeate; Carbon tetrachloride; Biochemical parameters; Antioxidants; Lipid peroxidation; Histopathology Pisonia aculeate; Carbon tetrachloride; Biochemical parameters; Antioxidants; Lipid peroxidation; Histopathology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

PALANIVEL, M.G.; RAJKAPOOR, B.; KUMAR, R.S.; EINSTEIN, J.W.; KUMAR, E.P.; KUMAR, M.R.; KAVITHA, K.; KUMAR, M.P.; JAYAKAR, B. Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats. Sci. Pharm. 2008, 76, 203-216.

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