Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats
AbstractEthanol extract of Pisonia aculeata (EPA) was evaluated for hepatoprotective and antioxidant activities in rats. The plant extract (250 and 500 mg/kg, p.o.) showed a remarkable hepatoprotective and antioxidant activity against carbon tetrachloride (CCl4)-induced hepatotoxicity as judged from the serum marker enzymes and antioxidant levels in liver tissues. CCl4-induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST). Treatment of rats with different doses of plant extract (250 and 500 mg/kg) significantly (P<0.001) altered serum marker enzymes and antioxidant levels to near normal against CCl4-treated rats. The activity of the extract at dose of 500 mg/kg was comparable to the standard drug, silymarin (50 mg/kg, p.o.). Histopathological changes of liver sample were compared with respective control. Results indicate the hepatoprotective and antioxidant properties of P. aculeata against CCl4-induced hepatotoxicity in rats.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
PALANIVEL, M.G.; RAJKAPOOR, B.; KUMAR, R.S.; EINSTEIN, J.W.; KUMAR, E.P.; KUMAR, M.R.; KAVITHA, K.; KUMAR, M.P.; JAYAKAR, B. Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats. Sci. Pharm. 2008, 76, 203-216.
PALANIVEL MG, RAJKAPOOR B, KUMAR RS, EINSTEIN JW, KUMAR EP, KUMAR MR, KAVITHA K, KUMAR MP, JAYAKAR B. Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats. Scientia Pharmaceutica. 2008; 76(2):203-216.Chicago/Turabian Style
PALANIVEL, Muthu G.; RAJKAPOOR, Balasubramanian; KUMAR, Raju S.; EINSTEIN, John W.; KUMAR, Ekambaram P.; KUMAR, Mani R.; KAVITHA, Kunchu; KUMAR, Mohanraj P.; JAYAKAR, Balasundaram. 2008. "Hepatoprotective and Antioxidant Effect of Pisonia aculeata L. against CCl4-Induced Hepatic Damage in Rats." Sci. Pharm. 76, no. 2: 203-216.