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Sci. Pharm. 2008, 76(2), 217-240; doi:10.3797/scipharm.0803-04 (registering DOI)

Synthesis, Characterization and Antimicrobial Studies on Some Newer Imidazole Analogs

Department of Pharmaceutical Chemistry, Rajiv Academy for Pharmacy, Mathura - 281001, Uttar Pradesh, India
Received: 14 March 2008 / Accepted: 14 April 2008 / Published: 17 April 2008
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Abstract

A novel series of 3,5-diiodo-4-(2-methyl-1H-imidazol-5-yl)benzoic acid analogs of amino acids, dipeptides and tripeptides was synthesized by using dicyclohexylcarbodiimide and diisopropylcarbodiimide (DCC/DIPC) as coupling agents and triethylamine (TEA) as base. Structures of all the newly synthesized compounds were confirmed by elemental analysis and IR, 1H NMR, 13C NMR and mass spectral data. Imidazolopeptides were investigated for their antimicrobial activity and some of newly synthesized compounds 2c, 2d, 2h and their hydrolyzed analogs 3b, 3d exhibited potent bioactivity against pathogenic fungi Candida albicans and dermatophytes Trichophyton mentagrophytes and Microsporum audouinii with MIC values of 12.5-6 μg/ml, as compared to the reference drug - griseofulvin. In addition, moderate activity against gram negative bacteria Pseudomonas aeruginosa and Klebsiella pneumoniae was also observed for synthesized imidazolopeptides.
Keywords: Imidazolopeptides; p-Amino-3,5-diiodobenzoic acid; Peptide coupling; Antifungal activity; Antibacterial activity Imidazolopeptides; p-Amino-3,5-diiodobenzoic acid; Peptide coupling; Antifungal activity; Antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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DAHIYA, R. Synthesis, Characterization and Antimicrobial Studies on Some Newer Imidazole Analogs. Sci. Pharm. 2008, 76, 217-240.

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