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Sci. Pharm. 2008, 76(2), 133-150; doi:10.3797/scipharm.0803-29 (registering DOI)

Rosiglitazone modifies PEDF gene expression and protein levels in the Koletsky rat choroid-RPE complex

1
Department of Physiology, Southern Illinois University School of Medicine
2
Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163
3
Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901
*
Author to whom correspondence should be addressed.
Received: 27 March 2008 / Accepted: 16 May 2008 / Published: 21 May 2008

Abstract

The purpose of this study was to determine whether rosiglitazone, a peroxisome proliferator-activated receptor (PPAR)γ ligand, altered growth factor expression in the choroid-RPE complex of Koletsky rats. Using lean and obese Koletsky rats fed a normal or rosiglitazone-supplemented diet, gene and protein expression of vascular endothelial growth factor (VEGF), pigment epithelial derived growth factor (PEDF), angiopoietin 1, and its receptor, Tie-2, were assessed. Both gene expression and protein expression of PEDF were significantly increased in both obese and lean Koletsky rats treated with rosiglitazone diet. Gene expression of VEGF, angiopoietin-1 and Tie-2 were increased after rosiglitazone treatment, without changes in protein expression. Since PPARγ ligands have been implicated in vascular remodeling, these results suggest that upregulation of PEDF expression may be a potential mechanism in the rat choroid-RPE complex.
Keywords: Choroid; Koletsky; Growth factors; PPAR gamma; RPE Choroid; Koletsky; Growth factors; PPAR gamma; RPE
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

STEINLE, J.J.; LASHBROOK, B.L.; BANZ, W.J. Rosiglitazone modifies PEDF gene expression and protein levels in the Koletsky rat choroid-RPE complex. Sci. Pharm. 2008, 76, 133-150.

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