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Sci. Pharm. 2007, 75(4), 179-193; doi:10.3797/scipharm.2007.75.179 (registering DOI)

Antioxidant Active Principles Isolated from Psidium guajava Grown in Thailand

1
Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand
2
Center for Environment, Health and Field Sciences, Chiba University, Japan
*
Author to whom correspondence should be addressed.
Received: 15 September 2007 / Accepted: 10 November 2007 / Published: 31 December 2007
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Abstract

Antioxidant active compounds were isolated from methanol crude extracts of the leaves of Guava (Psidium guajava L.) grown in Thailand. The isolated compounds were screened for their in vitro antioxidant activity by a DPPH free radical scavenging assay. Results indicate that three isolated compounds contribute importantly to the antioxidant activity of guava leaves, providing a scientific basis for the use of this plant in traditional medicine. Their structures were determined on the basis of spectroscopic and chemical methods. The most active compound was found to be quercetin along with two flavonoid compounds, quercetin-3-O-glucopyranoside and morin. The isolated quercetin, quercetin-3-O-glucopyranoside and morin showed significant scavenging activity with IC50 of 1.20±0.02, 3.58±0.05 and 5.41±0.20 µg/ml, respectively.
Keywords: Guava; Psidium guajava; Flavonoid; Antioxidant activity Guava; Psidium guajava; Flavonoid; Antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tachakittirungrod, S.; Ikegami, F.; Okonogi, S. Antioxidant Active Principles Isolated from Psidium guajava Grown in Thailand. Sci. Pharm. 2007, 75, 179-193.

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