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Sci. Pharm. 2007, 75(4), 171-178; doi:10.3797/scipharm.2007.75.171 (registering DOI)
Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC
nstitute of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
Author to whom correspondence should be addressed.
Received: 30 August 2007 / Accepted: 5 December 2007 / Published: 31 December 2007
Abstract HPLC was used to determine the content of methylparaben (MP), propylparaben (PP) and 4-hydroxybenzoic acid (4-HYB) as their decomposition product in the water solution Aqua Conservans (AQCO) in accordance with the Czech Pharmacopoeia and the Slovak Pharmaceutical Codex (0.067 % MP and 0.033 % PP). Based on the results of the analyses of 10 samples of AQCO from 8 pharmacies, 4-42 months after their preparation, an expiration period of 3 years was proposed for AQCO.
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Šubert, J.; Fars, O.; Marečková, M. Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Sci. Pharm. 2007, 75, 171-178.
Šubert J, Fars O, Marečková M. Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Scientia Pharmaceutica. 2007; 75(4):171-178.
Šubert, Jan; Fars, Oldřich; Marečková, Marie. 2007. "Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC." Sci. Pharm. 75, no. 4: 171-178.
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