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Sci. Pharm. 2007, 75(4), 171-178; doi:10.3797/scipharm.2007.75.171 (registering DOI)

Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC

nstitute of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
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Author to whom correspondence should be addressed.
Received: 30 August 2007 / Accepted: 5 December 2007 / Published: 31 December 2007
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Abstract

HPLC was used to determine the content of methylparaben (MP), propylparaben (PP) and 4-hydroxybenzoic acid (4-HYB) as their decomposition product in the water solution Aqua Conservans (AQCO) in accordance with the Czech Pharmacopoeia and the Slovak Pharmaceutical Codex (0.067 % MP and 0.033 % PP). Based on the results of the analyses of 10 samples of AQCO from 8 pharmacies, 4-42 months after their preparation, an expiration period of 3 years was proposed for AQCO.
Keywords: Parabens; Aqua Conservans; stability; 4-hydroxybenzoic acid; HPLC Parabens; Aqua Conservans; stability; 4-hydroxybenzoic acid; HPLC
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Šubert, J.; Fars, O.; Marečková, M. Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Sci. Pharm. 2007, 75, 171-178.

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