Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC
nstitute of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, 612 42 Brno, Czech Republic
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Author to whom correspondence should be addressed.
Sci. Pharm. 2007, 75(4), 171-178; https://doi.org/10.3797/scipharm.2007.75.171
Submission received: 30 August 2007
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Accepted: 5 December 2007
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Published: 31 December 2007
Abstract
HPLC was used to determine the content of methylparaben (MP), propylparaben (PP) and 4-hydroxybenzoic acid (4-HYB) as their decomposition product in the water solution Aqua Conservans (AQCO) in accordance with the Czech Pharmacopoeia and the Slovak Pharmaceutical Codex (0.067 % MP and 0.033 % PP). Based on the results of the analyses of 10 samples of AQCO from 8 pharmacies, 4-42 months after their preparation, an expiration period of 3 years was proposed for AQCO.
Keywords:
Parabens; Aqua Conservans; stability; 4-hydroxybenzoic acid; HPLC
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MDPI and ACS Style
Šubert, J.; Fars, O.; Marečková, M. Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Sci. Pharm. 2007, 75, 171-178. https://doi.org/10.3797/scipharm.2007.75.171
AMA Style
Šubert J, Fars O, Marečková M. Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC. Scientia Pharmaceutica. 2007; 75(4):171-178. https://doi.org/10.3797/scipharm.2007.75.171
Chicago/Turabian StyleŠubert, Jan, Oldřich Fars, and Marie Marečková. 2007. "Stability Evaluation of Methylparaben and Propylparaben in their Solution Aqua Conservans Using HPLC" Scientia Pharmaceutica 75, no. 4: 171-178. https://doi.org/10.3797/scipharm.2007.75.171
