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Diseases 2018, 6(3), 72; https://doi.org/10.3390/diseases6030072

Inhibitory Effects of Pulse Bioactive Compounds on Cancer Development Pathways

1
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
2
Australian Research Council (ARC) Industrial Transformation Training Centre (ITTC) for Functional Grains, Graham Centre for Agricultural Innovation, Charles Sturt University, Wagga Wagga, NSW 2650, Australia
*
Author to whom correspondence should be addressed.
Received: 9 July 2018 / Revised: 30 July 2018 / Accepted: 30 July 2018 / Published: 3 August 2018
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Abstract

Previous studies suggest that pulses may have the potential to protect against cancer development by inhibiting pathways that result in the development of cancer. These pathways include those that result in inflammation, DNA damage, cell proliferation, and metastasis. Other studies have demonstrated extracts from pulses have the capacity to induce apoptosis specifically in cancer cells. Compounds reported to be responsible for these activities have included phenolic compounds, proteins and short chain fatty acids. The majority of the studies have been undertaken using in vitro cell culture models, however, there are a small number of in vivo studies that support the hypothesis that pulse consumption may inhibit cancer development. This review highlights the potential benefit of a diet rich in pulse bioactive compounds by exploring the anti-cancer properties of its polyphenols, proteins and short chain fatty acids. View Full-Text
Keywords: pulses; anti-cancer; antioxidant; polyphenols; peptides pulses; anti-cancer; antioxidant; polyphenols; peptides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Rao, S.; Chinkwo, K.A.; Santhakumar, A.B.; Blanchard, C.L. Inhibitory Effects of Pulse Bioactive Compounds on Cancer Development Pathways. Diseases 2018, 6, 72.

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