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Diseases 2017, 5(1), 4; doi:10.3390/diseases5010004

Risk of Asymptomatic Bacteriuria among People with Sickle Cell Disease in Accra, Ghana

1
Department of Medical Microbiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana
2
Department of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 17 November 2016 / Revised: 31 January 2017 / Accepted: 7 February 2017 / Published: 15 February 2017
(This article belongs to the Section Infectious Disease)
View Full-Text   |   Download PDF [196 KB, uploaded 15 February 2017]

Abstract

Asymptomatic bacteriuria (ASB) is benign except in certain medical conditions such as pregnancy and immunosuppression. In Ghana, there are hardly any studies on urinary infections among sickle cell disease (SCD) patients, and the few studies carried out in Africa focused on pediatric SCD populations. The current study aimed to investigate the risk of ASB among SCD patients at a tertiary hospital in Ghana. This was a cross-sectional study involving 110 SCD patients and 110 age and sex matched healthy controls. Urine specimens were collected from all the study subjects and analyzed by standard microbiological methods. Demographic information were also collected from the study subjects. The overall ASB prevalence was significantly higher among SCD patients (17.2%) than among the control group (8.2%), and the relative risk was 2.11 (p = 0.0431; CI = 1.00–4.45). Being female was as a predictor of ASB among the SCD patients (OR = 14.76; CI = 11.23–18.29; p = 0.0103). The most common organism isolated from the study participants was coagulase negative Staphylococcus species (4.1%), followed by Escherichia coli (2.7%); etiology of ASB in the SCD patients was more diverse compared to healthy people. All the E. coli isolates were susceptible to amikacin, sparfloxacin and norfloxacin but resistant to ampicillin. View Full-Text
Keywords: bacteriuria; urine; Staphylococcus; sickle cell disease bacteriuria; urine; Staphylococcus; sickle cell disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Donkor, E.S.; Osei, J.A.; Anim-Baidoo, I.; Darkwah, S. Risk of Asymptomatic Bacteriuria among People with Sickle Cell Disease in Accra, Ghana. Diseases 2017, 5, 4.

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