Next Article in Journal
Human Coronaviruses: A Review of Virus–Host Interactions
Next Article in Special Issue
Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention
Previous Article in Journal / Special Issue
The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications
Article Menu

Export Article

Open AccessArticle
Diseases 2016, 4(3), 25; doi:10.3390/diseases4030025

Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC

1
Anesthesiology and Intensive Care, Laënnec Hospital, 44093 Nantes, France
2
Department of Dermatology and Venereology, Medical University of Innsbruck, Innsbruck, A-6020, Austria
3
Thoracic Surgery, Laënnec Hospital, 44093 Nantes, France
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 21 April 2016 / Revised: 11 July 2016 / Accepted: 11 July 2016 / Published: 14 July 2016
View Full-Text   |   Download PDF [692 KB, uploaded 14 July 2016]   |  

Abstract

Background: Singlet oxygen (1O2) oxidizes targets through the production of secondary reactive oxygen species (SOS). Cancers induce oxidative stress changing with progression, the resulting antioxidant status differing from one patient to the other. The aim of this study was to determine the oxidative status of patients with resectable Non-Small cell lung cancers (NSCLC) and the potential influence of antioxidants, compared to sera from healthy donors. Materials and Methods: Serum samples from 10 women and 28 men, 19 adenocarcinomas (ADK), 15 patients N1 or M1 were submitted to a photoreaction producing 1O2. Then, samples were supplemented with vitamins (Vit C, Vit E), or glutathione (GSH). Results: Squamous cell carcinomas (SCC) and metastatic SCCs induced a lower SOS rate. While Vit C increased SOS in controls as in patients with metastases, Vit E or the combination of Vit E and C strongly reduced SOS. GSH alone lightly decreased SOS in controls but had no effect in patients either alone or combined with Vit C. Conclusion: In “early” lung cancers, SOS are comparable or lower than for healthy persons. The role of Vitamins varies with gender, cancer type, and metastases. This suggests that an eventual supplementation should be performed on a per-patient basis to evidence any effect. View Full-Text
Keywords: NSCLC; singlet oxygen; reactive oxygen species (ROS); vitamin; glutathione NSCLC; singlet oxygen; reactive oxygen species (ROS); vitamin; glutathione
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Patrice, T.; Rozec, B.; Sidoroff, A.; Blanloeil, Y.; Despins, P.; Perrigaud, C. Influence of Vitamins on Secondary Reactive Oxygen Species Production in Sera of Patients with Resectable NSCLC. Diseases 2016, 4, 25.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diseases EISSN 2079-9721 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top