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Diseases 2015, 3(2), 56-67; doi:10.3390/diseases3020056

Growth Hormone Therapy in Adults with Prader-Willi Syndrome

Division of Endocrinology, Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, 20889, MD, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Danny Camfferman
Received: 14 March 2015 / Revised: 5 April 2015 / Accepted: 10 April 2015 / Published: 16 April 2015
(This article belongs to the Special Issue Prader-Willi Syndrome)
View Full-Text   |   Download PDF [667 KB, uploaded 16 April 2015]


Prader-Willi syndrome (PWS) is characterized by hyperphagia, obesity if food intake is not strictly controlled, abnormal body composition with decreased lean body mass and increased fat mass, decreased basal metabolic rate, short stature, low muscle tone, cognitive disability, and hypogonadism. In addition to improvements in linear growth, the benefits of growth hormone therapy on body composition and motor function in children with PWS are well established. Evidence is now emerging on the benefits of growth hormone therapy in adults with PWS. This review summarizes the current literature on growth hormone status and the use of growth hormone therapy in adults with PWS. The benefits of growth hormone therapy on body composition, muscle strength, exercise capacity, certain measures of sleep-disordered breathing, metabolic parameters, quality of life, and cognition are covered in detail along with potential adverse effects and guidelines for initiating and monitoring therapy. View Full-Text
Keywords: Prader-Willi; adult; growth hormone; body composition Prader-Willi; adult; growth hormone; body composition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vogt, K.S.; Emerick, J.E. Growth Hormone Therapy in Adults with Prader-Willi Syndrome. Diseases 2015, 3, 56-67.

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