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Diseases 2015, 3(1), 2-14; doi:10.3390/diseases3010002

Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root

Clinical Operational Research Unit, Department of Mathematics, University College London, Gower Street, London WC1E 6BT, UK
National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit (BRU), Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Author to whom correspondence should be addressed.
Academic Editor: Peter Varga
Received: 16 October 2014 / Accepted: 4 January 2015 / Published: 15 January 2015
(This article belongs to the Special Issue Marfan Syndrome: Recognition, Diagnosis and Managements)
View Full-Text   |   Download PDF [2534 KB, uploaded 15 January 2015]   |  


Personalised external aortic support was first proposed in 2000 by Tal Golesworthy, an engineer with familial Marfan syndrome and an aortic root aneurysm. After putting together a research and development team, and finding a surgeon to take on the challenge to join him in this innovative approach, he was central to the manufacture of the device, custom made for his own aorta. He was the patient for the ‘first in man’ operation in 2004. Ten years later he is well and 45 other people have had their own personalised device implanted. In this account, the stepwise record of proof of principle, comparative quantification of the surgical and perioperative requirements, 10 years of results, and development and research plans for the future are presented. View Full-Text
Keywords: Marfan syndrome; aortic root aneurysm; surgery Marfan syndrome; aortic root aneurysm; surgery

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Treasure, T.; Pepper, J. Personalised External Aortic Root Support (PEARS) Compared with Alternatives for People with Life-Threatening Genetically Determined Aneurysms of the Aortic Root. Diseases 2015, 3, 2-14.

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