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Diseases 2014, 2(4), 308-321; doi:10.3390/diseases2040308

Impact of Aging on Liver Histological Findings of Autoimmune Liver Diseases

Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba 260-8677, Japan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 8 October 2014 / Revised: 31 October 2014 / Accepted: 7 November 2014 / Published: 27 November 2014
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Our aim is to investigate the recent liver biopsy findings of autoimmune liver diseases at a university hospital located in an urban area of Japan. The study included 259 patients (mean age 56.8 ± 12.5; male/female, 46/213) who underwent a liver biopsy for primary biliary cirrhosis (PBC) or autoimmune hepatitis (AIH). We analyzed their liver biopsy findings according to age and gender. Among 127 PBC patients, Scheuer stages 1, 2, 3, and 4 were 42, 54, 18, and 13, respectively. Among 101 AIH patients, fibrosis stages F1, F2, F3, and F4 were 37, 32, 19, and 13, respectively, and inflammatory activity grades A1, A2, and A3 were 22, 25, and 54, respectively. Among PBC aged ≥65 years, Scheuer stages 1–3 and 4 patients were 27 and 6, respectively. The proportion of Scheuer stage 4 patients in PBC aged ≥65 years tended to be higher than that in PBC aged <65 years (p = 0.0659). Of interest, the proportion of AIH patients with moderate or severe activity (A2 or A3) in males was higher than in females (p = 0.0311). From the point of view of fibrosis stage or inflammatory activity grade of the liver, the proportion of AIH patients aged ≥65 years was similar to that aged <65 years. Although we identified six older cirrhotic patients with AIH, three of them were male. The progression of fibrosis and inflammatory activity of the liver should be noted when we treat older patients suffering from autoimmune liver diseases. Liver biopsy plays an important role in obtaining accurate information on autoimmune liver diseases in older patients. View Full-Text
Keywords: autoimmune hepatitis; hepatic fibrosis; liver biopsy; primary biliary cirrhosis; staging of fibrosis autoimmune hepatitis; hepatic fibrosis; liver biopsy; primary biliary cirrhosis; staging of fibrosis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Haga, Y.; Kanda, T.; Hagiwara, K.; Sasaki, R.; Nakamura, M.; Yasui, S.; Arai, M.; Jiang, X.; Wu, S.; Nakamoto, S.; Yokosuka, O. Impact of Aging on Liver Histological Findings of Autoimmune Liver Diseases. Diseases 2014, 2, 308-321.

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