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Biology 2017, 6(1), 1; doi:10.3390/biology6010001

Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments

1
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
2
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: J. Richard McIntosh
Received: 3 November 2016 / Revised: 24 December 2016 / Accepted: 28 December 2016 / Published: 5 January 2017
(This article belongs to the Special Issue Mechanisms of Mitotic Chromosome Segregation)
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Abstract

In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole. The exact sequence of events by which this goal is achieved varies considerably from cell to cell because of the variable locations of kinetochores and spindle poles, and randomness of initial microtubule attachments. These chance encounters with the kinetochores nonetheless ultimately lead to the desired outcome with high fidelity and in a limited time frame, providing one of the most startling examples of biological self-organization. This chapter discusses mechanisms that contribute to accurate chromosome segregation by helping dividing cells to avoid and resolve improper microtubule attachments. View Full-Text
Keywords: Aurora B kinase; kinetochore geometry; microtubule turnover; tension-dependent regulation Aurora B kinase; kinetochore geometry; microtubule turnover; tension-dependent regulation
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Lampson, M.A.; Grishchuk, E.L. Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments. Biology 2017, 6, 1.

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