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Biology 2016, 5(4), 38; doi:10.3390/biology5040038

Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations

1
Graduate School of Sports and Health Science, Doshisha University, Kyoto 610-0394, Japan
2
Faculty of Sports and Health Science, Doshisha University, Kyoto 610-0394, Japan
*
Author to whom correspondence should be addressed.
Received: 2 August 2016 / Accepted: 28 September 2016 / Published: 8 October 2016
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Abstract

Lactate (or its protonated form: lactic acid) has been studied by many exercise scientists. The lactate paradigm has been in constant change since lactate was first discovered in 1780. For many years, it was unfairly seen as primarily responsible for muscular fatigue during exercise and a waste product of glycolysis. The status of lactate has slowly changed to an energy source, and in the last two decades new evidence suggests that lactate may play a much bigger role than was previously believed: many adaptations to exercise may be mediated in some way by lactate. The mechanisms behind these adaptations are yet to be understood. The aim of this review is to present the state of lactate science, focusing on how this molecule may mediate exercise-induced adaptations. View Full-Text
Keywords: lactate; signaling molecule; HIF-1; PGC-1 alpha lactate; signaling molecule; HIF-1; PGC-1 alpha
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nalbandian, M.; Takeda, M. Lactate as a Signaling Molecule That Regulates Exercise-Induced Adaptations. Biology 2016, 5, 38.

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