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Biology 2015, 4(1), 104-132; doi:10.3390/biology4010104

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism

1
Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, 14186, Sweden
2
Strategy and Externalization, CVMD iMED, AstraZeneca, R&D, Mölndal, SE-431 83, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Annette Graham
Received: 10 December 2014 / Accepted: 28 January 2015 / Published: 5 February 2015
(This article belongs to the Special Issue Lipid Metabolism)
View Full-Text   |   Download PDF [954 KB, uploaded 10 February 2015]   |  

Abstract

Disorders of lipid and lipoprotein metabolism and transport are responsible for the development of a large spectrum of pathologies, ranging from cardiovascular diseases, to metabolic syndrome, even to tumour development. Recently, a deeper knowledge of the molecular mechanisms that control our biological clock and circadian rhythms has been achieved. From these studies it has clearly emerged how the molecular clock tightly regulates every aspect of our lives, including our metabolism. This review analyses the organisation and functioning of the circadian clock and its relevance in the regulation of physiological processes. We also describe metabolism and transport of lipids and lipoproteins as an essential aspect for our health, and we will focus on how the circadian clock and lipid metabolism are greatly interconnected. Finally, we discuss how a deeper knowledge of this relationship might be useful to improve the recent spread of metabolic diseases. View Full-Text
Keywords: circadian clock; central oscillator; peripheral oscillators; lipid metabolism; lipid transport; metabolic diseases circadian clock; central oscillator; peripheral oscillators; lipid metabolism; lipid transport; metabolic diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gnocchi, D.; Pedrelli, M.; Hurt-Camejo, E.; Parini, P. Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism. Biology 2015, 4, 104-132.

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