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Biology 2014, 3(4), 801-830; doi:10.3390/biology3040801

Glycerophosphate/Acylglycerophosphate Acyltransferases

Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan
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Received: 12 September 2014 / Revised: 2 November 2014 / Accepted: 5 November 2014 / Published: 19 November 2014
(This article belongs to the Special Issue Lipid Metabolism)
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Abstract

Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol (TAG) and glycerophospholipids. Many enzymes belonging to the GPAT/AGPAT family have recently been identified and their physiological or pathophysiological roles have been proposed. The roles of GPAT/AGPAT in the synthesis of TAG and obesity-related diseases were revealed through the identification of causative genes of these diseases or analyses of genetically manipulated animals. Recent studies have suggested that some isoforms of GPAT/AGPAT family enzymes are involved in the fatty acid remodeling of phospholipids. The enzymology of GPAT/AGPAT and their physiological/ pathological roles in the metabolism of glycerolipids have been described and discussed in this review. View Full-Text
Keywords: acyltransferase; acyl-CoA; triacylglycerol; phospholipid; GPAT; AGPAT acyltransferase; acyl-CoA; triacylglycerol; phospholipid; GPAT; AGPAT
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yamashita, A.; Hayashi, Y.; Matsumoto, N.; Nemoto-Sasaki, Y.; Oka, S.; Tanikawa, T.; Sugiura, T. Glycerophosphate/Acylglycerophosphate Acyltransferases. Biology 2014, 3, 801-830.

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