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Biology 2014, 3(3), 551-559; doi:10.3390/biology3030551

Elevated Circulating TNF-α in Fat-Free Mass Non-Responders Compared to Responders Following Exercise Training in Older Women

1
Department of Human Studies, University of Alabama-Birmingham, Birmingham, AL 35294, USA
2
Department of Physical Therapy, University of Alabama-Birmingham, Birmingham, AL 35294, USA
*
Author to whom correspondence should be addressed.
Received: 24 June 2014 / Revised: 14 August 2014 / Accepted: 26 August 2014 / Published: 5 September 2014
(This article belongs to the Special Issue Muscle Structure and Function)
View Full-Text   |   Download PDF [101 KB, uploaded 5 September 2014]   |  

Abstract

The purpose of this investigation was to determine if differences in inflammatory cytokines exist between fat-free mass responders versus non-responders following a combined resistance/aerobic training program in older women. Fifty women over 60 years old, mean BMI 27 ± 4 (kg/m2) and physically untrained, participated in a combined training program for 16-weeks. Body composition, muscle strength, and serum inflammatory markers (TNF-α, CRP, and IL-6) were assessed at baseline and 16-weeks post-training. A significant time effect was observed for weight, %fat, fat mass, and all strength measures (p < 0.05). A group interaction was observed for TNF-α (p < 0.05), which revealed higher concentrations of circulating TNF-α at baseline (18%) and post-exercise training (24%) in non-responders compared to responders (p < 0.05). In conclusion, this study revealed a significantly greater concentration of circulating TNF-α in older women that do not increase fat-free mass following training. View Full-Text
Keywords: combined exercise training; inflammation; hypertrophy; elderly combined exercise training; inflammation; hypertrophy; elderly
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Fisher, G.; Bickel, C.S.; Hunter, G.R. Elevated Circulating TNF-α in Fat-Free Mass Non-Responders Compared to Responders Following Exercise Training in Older Women. Biology 2014, 3, 551-559.

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