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Biology 2014, 3(3), 498-513; doi:10.3390/biology3030498

Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms

1
Genetics and Molecular Biology Program, Emory University, Atlanta, GA 30322, USA
2
Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
3
Division of Maternal-Fetal Medicine Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA
4
The Perinatal Research Center, Nashville, TN 37203, USA
5
Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
*
Author to whom correspondence should be addressed.
Received: 26 May 2014 / Revised: 8 August 2014 / Accepted: 12 August 2014 / Published: 21 August 2014
(This article belongs to the Special Issue DNA Methylation)
View Full-Text   |   Download PDF [149 KB, uploaded 21 August 2014]   |  

Abstract

The epigenetic patterns established during development may influence gene expression over a lifetime and increase susceptibility to chronic disease. Being born preterm (<37 weeks of gestation) is associated with increased risk mortality and morbidity from birth until adulthood. This brief review explores the potential role of DNA methylation in preterm birth (PTB) and its possible long-term consequences and provides an overview of the physiological processes central to PTB and recent DNA methylation studies of PTB. View Full-Text
Keywords: DNA methylation; preterm birth; pregnancy; DOHaD; epigenetic; developmental programming; gestational age DNA methylation; preterm birth; pregnancy; DOHaD; epigenetic; developmental programming; gestational age
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Parets, S.E.; Bedient, C.E.; Menon, R.; Smith, A.K. Preterm Birth and Its Long-Term Effects: Methylation to Mechanisms. Biology 2014, 3, 498-513.

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