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Biology 2014, 3(1), 22-38; doi:10.3390/biology3010022

Contemporary Network Proteomics and Its Requirements

1,* , 1
1 School of Computing, National University of Singapore, 13 Computing Drive, Singapore 117417, Singapore 2 Department of Physiology, National University of Singapore, 2 Medical Drive, Singapore 117597, Singapore 3 Neuroepigenetics Laboratory, Growth, Development and Metabolism Programme, Singapore Institute for Clinical Sciences, Agency for Science and Technology (A*STAR), Singapore 117609, Singapore
* Author to whom correspondence should be addressed.
Received: 12 November 2013 / Revised: 15 December 2013 / Accepted: 16 December 2013 / Published: 20 December 2013
(This article belongs to the Special Issue Advances in Proteomics Methods)
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The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expanded data coverage and consistency, and (2) suitable reference network libraries, and data mining from them. Concerning (1) we discuss several contemporary themes that can improve data quality, which in turn will boost the outcome of downstream network analysis. For (2), we focus on network analysis developments, specifically, the need for context-specific networks and essential considerations for localized network analysis.
Keywords: proteomics; networks; systems biology; bioinformatics proteomics; networks; systems biology; bioinformatics
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Goh, W.W.B.; Wong, L.; Sng, J.C.G. Contemporary Network Proteomics and Its Requirements. Biology 2014, 3, 22-38.

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