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Biology 2014, 3(1), 22-38; doi:10.3390/biology3010022
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Contemporary Network Proteomics and Its Requirements

1,* , 1
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2,3
Received: 12 November 2013 / Revised: 15 December 2013 / Accepted: 16 December 2013 / Published: 20 December 2013
(This article belongs to the Special Issue Advances in Proteomics Methods)
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Abstract

The integration of networks with genomics (network genomics) is a familiar field. Conventional network analysis takes advantage of the larger coverage and relative stability of gene expression measurements. Network proteomics on the other hand has to develop further on two critical factors: (1) expanded data coverage and consistency, and (2) suitable reference network libraries, and data mining from them. Concerning (1) we discuss several contemporary themes that can improve data quality, which in turn will boost the outcome of downstream network analysis. For (2), we focus on network analysis developments, specifically, the need for context-specific networks and essential considerations for localized network analysis.
Keywords: proteomics; networks; systems biology; bioinformatics proteomics; networks; systems biology; bioinformatics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Goh, W.W.B.; Wong, L.; Sng, J.C.G. Contemporary Network Proteomics and Its Requirements. Biology 2014, 3, 22-38.

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