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Hepatitis C Virus and Hepatocellular Carcinoma
Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
Yamanashi Hospitals (Central and Kita) Organization, 1-1-1 Fujimi, Koufu-shi, Yamanashi 400-8506, Japan
University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
* Authors to whom correspondence should be addressed.
Received: 4 January 2013; in revised form: 18 January 2013 / Accepted: 23 January 2013 / Published: 30 January 2013
Abstract: Hepatitis C virus (HCV), a hepatotropic virus, is a single stranded-positive RNA virus of ~9,600 nt. length belonging to the Flaviviridae family. HCV infection causes acute hepatitis, chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). It has been reported that HCV-coding proteins interact with host-cell factors that are involved in cell cycle regulation, transcriptional regulation, cell proliferation and apoptosis. Severe inflammation and advanced liver fibrosis in the liver background are also associated with the incidence of HCV-related HCC. In this review, we discuss the mechanism of hepatocarcinogenesis in HCV-related liver diseases.
Keywords: androgen receptor; apoptosis; gender difference; hepatitis C virus; hepatocellular carcinoma; inflammation
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MDPI and ACS Style
Kanda, T.; Yokosuka, O.; Omata, M. Hepatitis C Virus and Hepatocellular Carcinoma. Biology 2013, 2, 304-316.
Kanda T, Yokosuka O, Omata M. Hepatitis C Virus and Hepatocellular Carcinoma. Biology. 2013; 2(1):304-316.
Kanda, Tatsuo; Yokosuka, Osamu; Omata, Masao. 2013. "Hepatitis C Virus and Hepatocellular Carcinoma." Biology 2, no. 1: 304-316.