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Biology 2012, 1(3), 658-667; doi:10.3390/biology1030658
Article
Methods, Challenges and Potentials of Single Cell RNA-seq
The University of Warwick, School of Life Sciences, Coventry CV4 7AL, UK
Received: 24 October 2012; in revised form: 24 October 2012 / Accepted: 7 November 2012 / Published: 16 November 2012
(This article belongs to the Special Issue Next Generation Sequencing Approaches in Biology)
Download PDF Full-Text [221 KB, uploaded 16 November 2012 08:01 CET]
Abstract: RNA-sequencing (RNA-seq) has become the tool of choice for transcriptomics. Several recent studies demonstrate its successful adaption to single cell analysis. This allows new biological insights into cell differentiation, cell-to-cell variation and gene regulation, and how these aspects depend on each other. Here, I review the current single cell RNA-seq (scRNA-seq) efforts and discuss experimental protocols, challenges and potentials.
Keywords: RNA-seq; scRNA-seq; single cell
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MDPI and ACS Style
Hebenstreit, D. Methods, Challenges and Potentials of Single Cell RNA-seq. Biology 2012, 1, 658-667.
AMA StyleHebenstreit D. Methods, Challenges and Potentials of Single Cell RNA-seq. Biology. 2012; 1(3):658-667.
Chicago/Turabian StyleHebenstreit, Daniel. 2012. "Methods, Challenges and Potentials of Single Cell RNA-seq." Biology 1, no. 3: 658-667.