Next Article in Journal
Surface Functionalization of “Rajshahi Silk” Using Green Silver Nanoparticles
Previous Article in Journal
Effects of Surfactants on the Morphology and Properties of Electrospun Polyetherimide Fibers
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessArticle
Fibers 2017, 5(3), 34; doi:10.3390/fib5030034

Antimicrobial Electrospun Fibers of Polyester Loaded with Engineered Cyclic Gramicidin Analogues

1
Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Edifici I.2, C/Eduard Maristany, 10-14, 08019 Barcelona, Spain
2
Research Center for Multiscale Science and Engineering, Universitat Politècnica de Catalunya, C/Eduard Maristany, 10-14, 08019 Barcelona, Spain
3
Departamento de Química Orgánica, Instituto de Síntesis Química y Catálisis Homogénea-ISQCH, CSIC-Universidad de Zaragoza, C/Pedro Cerbuna, 12, 50009 Zaragoza, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Stephen C. Bondy
Received: 30 June 2017 / Revised: 26 July 2017 / Accepted: 21 August 2017 / Published: 11 September 2017
View Full-Text   |   Download PDF [4916 KB, uploaded 11 September 2017]   |  

Abstract

Biodegradable polyester fibers have been loaded with two engineered analogues of gramicidin soviet. In these cyclic peptide derivatives, which were designed in a previous work to stabilize the bioactive conformation while enhancing the antimicrobial activity, the D-Phe was replaced by D-Pro, and the L-Pro was changed by 1-aminocyclopropanecarboxylic acid (Ac3c) or by an Ac3c derivative with two vicinal phenyl substituents in a trans relative disposition (S,S-c3diPhe). The diameter, topography, thermal stability and wettability of the polyester fibers, which have been obtained by electrospinning, strongly depend on the molecular constraints and stability of the loaded peptides. More specifically, unloaded and linear gramicidin-loaded fibers (used as control) are hydrophobic, rough and micrometric, while fibers loaded with the cyclic peptides are hydrophilic, ultra-smooth, nanometric and less thermally stable. The activity of the two cyclic peptides increases when loaded into polyester fibers, suggesting that the polymeric matrix stabilizes the bioactive β-sheet structure. The peptide with S,S-c3diPhe displays higher antibiotic potency and biocompatibility than that with Ac3c, which indicates not only that the bioactive conformation is better preserved by the former but also the significant role played by the phenyl rings in the recognition by living cells. View Full-Text
Keywords: biocompatibility; conformational restrictions; encapsulation; electrospinning; engineered peptides; hydrophobic peptides biocompatibility; conformational restrictions; encapsulation; electrospinning; engineered peptides; hydrophobic peptides
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Maione, S.; del Valle, L.J.; Pérez-Madrigal, M.M.; Cativiela, C.; Puiggalí, J.; Alemán, C. Antimicrobial Electrospun Fibers of Polyester Loaded with Engineered Cyclic Gramicidin Analogues. Fibers 2017, 5, 34.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Fibers EISSN 2079-6439 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top