Coatings 2012, 2(3), 95-119; doi:10.3390/coatings2030095
Review

Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces

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Received: 15 May 2012; in revised form: 7 June 2012 / Accepted: 19 June 2012 / Published: 2 July 2012
(This article belongs to the Special Issue Advances in Organic Coatings)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The mechanical and biological properties of bone implants need to be optimal to form a quick and firm connection with the surrounding environment in load bearing applications. Bone is a connective tissue composed of an organic collagenous matrix, a fine dispersion of reinforcing inorganic (calcium phosphate) nanocrystals, and bone-forming and -degrading cells. These different components have a synergistic and hierarchical structure that renders bone tissue properties unique in terms of hardness, flexibility and regenerative capacity. Metallic and polymeric materials offer mechanical strength and/or resilience that are required to simulate bone tissue in load-bearing applications in terms of maximum load, bending and fatigue strength. Nevertheless, the interaction between devices and the surrounding tissue at the implant interface is essential for success or failure of implants. In that respect, coatings can be applied to facilitate the process of bone healing and obtain a continuous transition from living tissue to the synthetic implant. Compounds that are inspired by inorganic (e.g., hydroxyapatite crystals) or organic (e.g., collagen, extracellular matrix components, enzymes) components of bone tissue, are the most obvious candidates for application as implant coating to improve the performance of bone implants. This review provides an overview of recent trends and strategies in surface engineering that are currently investigated to improve the biological performance of bone implants in terms of functionality and biological efficacy.
Keywords: inorganic; organic; composites; plasma spray; surface modifications; bone; implants; coating techniques
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MDPI and ACS Style

Bosco, R.; Van Den Beucken, J.; Leeuwenburgh, S.; Jansen, J. Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces. Coatings 2012, 2, 95-119.

AMA Style

Bosco R, Van Den Beucken J, Leeuwenburgh S, Jansen J. Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces. Coatings. 2012; 2(3):95-119.

Chicago/Turabian Style

Bosco, Ruggero; Van Den Beucken, Jeroen; Leeuwenburgh, Sander; Jansen, John. 2012. "Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces." Coatings 2, no. 3: 95-119.

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