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Antibiotics 2018, 7(3), 72; https://doi.org/10.3390/antibiotics7030072

DnaG Primase—A Target for the Development of Novel Antibacterial Agents

Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
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Received: 18 July 2018 / Revised: 6 August 2018 / Accepted: 9 August 2018 / Published: 13 August 2018
(This article belongs to the Special Issue Bacterial DNA Replication and Replication Inhibitors)
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Abstract

The bacterial primase—an essential component in the replisome—is a promising but underexploited target for novel antibiotic drugs. Bacterial primases have a markedly different structure than the human primase. Inhibition of primase activity is expected to selectively halt bacterial DNA replication. Evidence is growing that halting DNA replication has a bacteriocidal effect. Therefore, inhibitors of DNA primase could provide antibiotic agents. Compounds that inhibit bacterial DnaG primase have been developed using different approaches. In this paper, we provide an overview of the current literature on DNA primases as novel drug targets and the methods used to find their inhibitors. Although few inhibitors have been identified, there are still challenges to develop inhibitors that can efficiently halt DNA replication and may be applied in a clinical setting. View Full-Text
Keywords: DNA replication; DnaG primase; bacterial inhibitors; antibacterial agents; antibiotics DNA replication; DnaG primase; bacterial inhibitors; antibacterial agents; antibiotics
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Ilic, S.; Cohen, S.; Singh, M.; Tam, B.; Dayan, A.; Akabayov, B. DnaG Primase—A Target for the Development of Novel Antibacterial Agents. Antibiotics 2018, 7, 72.

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