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Antibiotics 2018, 7(3), 54; https://doi.org/10.3390/antibiotics7030054

Management of Primary and Recurrent Clostridium difficile Infection: An Update

1
University of British Columbia Medical School, Vancouver, BC V6T 1Z3, Canada
2
Vancouver Island Health Authority, Victoria, BC V8R 1J8, Canada
3
Department of Pathology and Molecular Medicine, McMaster University, St Joseph’s Healthcare, Hamilton, ON L8S 4K1, Canada
4
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z2, Canada
*
Author to whom correspondence should be addressed.
Received: 7 May 2018 / Revised: 25 June 2018 / Accepted: 27 June 2018 / Published: 30 June 2018
Full-Text   |   PDF [213 KB, uploaded 30 June 2018]

Abstract

Background: Clostridium difficile infection (CDI) is one of the most common healthcare-associated infections (HAI) in the United States and Canada, and incidence rates have increased worldwide in recent decades. Currently, antibiotics are the mainstay treatments for both primary and recurrent CDI, but their efficacy is limited, prompting further therapies to be developed. Aim: This review summarizes current and emerging therapies in CDI management including antibiotics, fecal microbiota transplantation, monoclonal antibodies, spore-based therapies, and vaccinations. View Full-Text
Keywords: Clostridium difficile infection; healthcare-associated infections; antibiotics; fecal microbiota transplantation Clostridium difficile infection; healthcare-associated infections; antibiotics; fecal microbiota transplantation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Chai, J.; Lee, C.H. Management of Primary and Recurrent Clostridium difficile Infection: An Update. Antibiotics 2018, 7, 54.

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