Techniques for Screening Translation Inhibitors
AbstractThe machinery of translation is one of the most common targets of antibiotics. The development and screening of new antibiotics usually proceeds by testing antimicrobial activity followed by laborious studies of the mechanism of action. High-throughput methods for new antibiotic screening based on antimicrobial activity have become routine; however, identification of molecular targets is usually a challenge. Therefore, it is highly beneficial to combine primary screening with the identification of the mechanism of action. In this review, we describe a collection of methods for screening translation inhibitors, with a special emphasis on methods which can be performed in a high-throughput manner. View Full-Text
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Osterman, I.A.; Bogdanov, A.A.; Dontsova, O.A.; Sergiev, P.V. Techniques for Screening Translation Inhibitors. Antibiotics 2016, 5, 22.
Osterman IA, Bogdanov AA, Dontsova OA, Sergiev PV. Techniques for Screening Translation Inhibitors. Antibiotics. 2016; 5(3):22.Chicago/Turabian Style
Osterman, Ilya A.; Bogdanov, Alexey A.; Dontsova, Olga A.; Sergiev, Petr V. 2016. "Techniques for Screening Translation Inhibitors." Antibiotics 5, no. 3: 22.