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Antibiotics 2015, 4(3), 379-396; doi:10.3390/antibiotics4030379

Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria

1
and
1,2,*
1
School of Biological Sciences, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China
2
Institute of Scientific and Industrial Research, Osaka University, Yamadaoka 1-1, Suita, Osaka 565-0871, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Helen I. Zgurskaya
Received: 26 June 2015 / Revised: 11 August 2015 / Accepted: 13 August 2015 / Published: 28 August 2015
(This article belongs to the Special Issue Multi-drug Efflux and Drug Permeation)
View Full-Text   |   Download PDF [697 KB, uploaded 28 August 2015]   |  

Abstract

Active drug efflux constitutes an important mechanism of antibiotic and multidrug resistance in bacteria. Understanding the distribution, expression, and physiological functions of multidrug efflux pumps, especially under physiologically and clinically relevant conditions of the pathogens, is the key to combat drug resistance. In animal hosts, most wounded, infected and inflamed tissues display low oxygen tensions. In this article, we summarize research development on multidrug efflux pumps in the medicinally relevant microaerobic and anaerobic pathogens and their implications in the effort to combat drug-resistant infections. View Full-Text
Keywords: multi-drug efflux pump; microaerobic bacteria; anaerobic bacteria; efflux pump inhibitors multi-drug efflux pump; microaerobic bacteria; anaerobic bacteria; efflux pump inhibitors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xu, Z.; Yan, A. Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria. Antibiotics 2015, 4, 379-396.

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