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Biosensors 2016, 6(4), 51; doi:10.3390/bios6040051

Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

1
UCIBIO, REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Monte de Caparica, Portugal
2
Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Av. da República, 2780-157 Oeiras, Portugal
3
Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, 2829-511 Caparica, Portugal
*
Author to whom correspondence should be addressed.
Academic Editors: Donatella Albanese and Roberto Pilloton
Received: 9 August 2016 / Revised: 14 September 2016 / Accepted: 22 September 2016 / Published: 28 September 2016
(This article belongs to the Special Issue Screen-Printed Electrodes and Sensors)
View Full-Text   |   Download PDF [871 KB, uploaded 28 September 2016]   |  

Abstract

From the bench-mark work on microfluidics from the Whitesides’s group in 2007, paper technology has experienced significant growth, particularly regarding applications in biomedical research and clinical diagnostics. Besides the structural properties supporting microfluidics, other advantageous features of paper materials, including their versatility, disposability and low cost, show off the great potential for the development of advanced and eco-friendly analytical tools. Consequently, paper was quickly employed in the field of electrochemical sensors, being an ideal material for producing custom, tailored and miniaturized devices. Stencil-, inkjet-, or screen-printing are the preferential techniques for electrode manufacturing. Not surprisingly, we witnessed a rapid increase in the number of publications on paper based screen-printed sensors at the turn of the past decade. Among the sensing strategies, various biosensors, coupling electrochemical detectors with biomolecules, have been proposed. This work provides a critical review and a discussion on the future progress of paper technology in the context of miniaturized printed electrochemical biosensors. View Full-Text
Keywords: paper analytical device; printed electrodes; wax patterning; biosensors. paper analytical device; printed electrodes; wax patterning; biosensors.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Silveira, C.M.; Monteiro, T.; Almeida, M.G. Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend. Biosensors 2016, 6, 51.

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