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Biosensors 2016, 6(3), 42; doi:10.3390/bios6030042

Nanopore-CMOS Interfaces for DNA Sequencing

Department of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, Canada
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Author to whom correspondence should be addressed.
Academic Editor: Jeff D. Newman
Received: 31 May 2016 / Revised: 18 July 2016 / Accepted: 28 July 2016 / Published: 6 August 2016
(This article belongs to the Special Issue Micro- and Nano-Bio-Interfaces)

Abstract

DNA sequencers based on nanopore sensors present an opportunity for a significant break from the template-based incumbents of the last forty years. Key advantages ushered by nanopore technology include a simplified chemistry and the ability to interface to CMOS technology. The latter opportunity offers substantial promise for improvement in sequencing speed, size and cost. This paper reviews existing and emerging means of interfacing nanopores to CMOS technology with an emphasis on massively-arrayed structures. It presents this in the context of incumbent DNA sequencing techniques, reviews and quantifies nanopore characteristics and models and presents CMOS circuit methods for the amplification of low-current nanopore signals in such interfaces. View Full-Text
Keywords: nanopore sensors; microelectronics; sequencing; CMOS; nanopore arrays; transimpedance amplification nanopore sensors; microelectronics; sequencing; CMOS; nanopore arrays; transimpedance amplification
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Magierowski, S.; Huang, Y.; Wang, C.; Ghafar-Zadeh, E. Nanopore-CMOS Interfaces for DNA Sequencing. Biosensors 2016, 6, 42.

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