Biosensors 2012, 2(1), 70-82; doi:10.3390/bios2010070

Poly(lactic acid)/Carbon Nanotube Fibers as Novel Platforms for Glucose Biosensors

1email, 2email, 3email and 4,* email
Received: 16 January 2012; in revised form: 11 February 2012 / Accepted: 24 February 2012 / Published: 27 February 2012
(This article belongs to the Special Issue Electrochemical Based Biosensors)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The focus of this paper is the development and investigation of properties of new nanostructured architecture for biosensors applications. Highly porous nanocomposite fibers were developed for use as active materials in biosensors. The nanocomposites comprised poly(lactic acid)(PLA)/multi-walled carbon nanotube (MWCNT) fibers obtained via solution-blow spinning onto indium tin oxide (ITO) electrodes. The electrocatalytic properties of nanocomposite-modified ITO electrodes were investigated toward hydrogen peroxide (H2O2) detection. We investigated the effect of carbon nanotube concentration and the time deposition of fibers on the sensors properties, viz., sensitivity and limit of detection. Cyclic voltammetry experiments revealed that the nanocomposite-modified electrodes displayed enhanced activity in the electrochemical reduction of H2O2, which offers a number of attractive features to be explored in development of an amperometric biosensor. Glucose oxidase (GOD) was further immobilized by drop coating on an optimized ITO electrode covered by poly(lactic acid)/carbon nanotube nanofibrous mats. The optimum biosensor response was linear up to 800 mM of glucose with a sensitivity of 358 nA·mM−1 and a Michaelis-Menten constant (KM) of 4.3 mM. These results demonstrate that the solution blow spun nanocomposite fibers have great potential for application as amperometric biosensors due to their high surface to volume ratio, high porosity and permeability of the substrate. The latter features may significantly enhance the field of glucose biosensors.
Keywords: nanofibers; glucose biosensor; carbon nanotube; poly(lactic acid)
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MDPI and ACS Style

Oliveira, J.E.; Mattoso, L.H.C.; Medeiros, E.S.; Zucolotto, V. Poly(lactic acid)/Carbon Nanotube Fibers as Novel Platforms for Glucose Biosensors. Biosensors 2012, 2, 70-82.

AMA Style

Oliveira JE, Mattoso LHC, Medeiros ES, Zucolotto V. Poly(lactic acid)/Carbon Nanotube Fibers as Novel Platforms for Glucose Biosensors. Biosensors. 2012; 2(1):70-82.

Chicago/Turabian Style

Oliveira, Juliano Elvis; Mattoso, Luiz Henrique Capparelli; Medeiros, Eliton Souto; Zucolotto, Valtencir. 2012. "Poly(lactic acid)/Carbon Nanotube Fibers as Novel Platforms for Glucose Biosensors." Biosensors 2, no. 1: 70-82.

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