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Biosensors 2012, 2(1), 1-14; doi:10.3390/bios2010001

Graphene and Other Nanomaterial-Based Electrochemical Aptasensors

1,*  and 2
1 Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 375 Newton Rd, Iowa City, IA 52242, USA 2 Institute for Polymer Materials (Polymat), University of the Basque Country, Avda. Tolosa 72, San Sebastian 20018, Spain
* Author to whom correspondence should be addressed.
Received: 21 November 2011 / Revised: 22 December 2011 / Accepted: 12 January 2012 / Published: 13 January 2012
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Electrochemical aptasensors, which are based on the specificity of aptamer-target recognition, with electrochemical transduction for analytical purposes have received particular attention due to their high sensitivity and selectivity, simple instrumentation, as well as low production cost. Aptamers are functional nucleic acids with specific and high affinity to their targets, similar to antibodies. However, they are completely selected in vitro in contrast to antibodies. Due to their stability, easy chemical modifications and proneness to nanostructured device construction, aptamer-based sensors have been incorporated in a variety of applications including electrochemical sensing devices. In recent years, the performance of aptasensors has been augmented by incorporating novel nanomaterials in the preparation of better electrochemical sensors. In this review, we summarize the recent trends in the use of nanomaterials for developing electrochemical aptasensors.
Keywords: aptamers; aptasensors; biosensors; electrochemistry; nanobiotechnology; graphene; carbon nanotubes aptamers; aptasensors; biosensors; electrochemistry; nanobiotechnology; graphene; carbon nanotubes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hernandez, F.J.; Ozalp, V.C. Graphene and Other Nanomaterial-Based Electrochemical Aptasensors. Biosensors 2012, 2, 1-14.

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