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Nanomaterials 2018, 8(6), 449; https://doi.org/10.3390/nano8060449

Spherical and Spindle-Like Abamectin-Loaded Nanoparticles by Flash Nanoprecipitation for Southern Root-Knot Nematode Control: Preparation and Characterization

1
State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
2
Engineering Research Center of Materials Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Xinjiang 832000, China
3
Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China
*
Authors to whom correspondence should be addressed.
Received: 30 May 2018 / Revised: 14 June 2018 / Accepted: 18 June 2018 / Published: 20 June 2018
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Abstract

Southern root-knot nematode (Meloidogyne incognita) is a biotrophic parasite, causing enormous loss in global crop production annually. Abamectin (Abm) is a biological and high-efficiency pesticide against Meloidogyne incognita. In this study, a powerful method, flash nanoprecipitation (FNP), was adopted to successfully produce Abm-loaded nanoparticle suspensions with high drug loading capacity (>40%) and encapsulation efficiency (>95%), where amphiphilic block copolymers (BCPs) poly(lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG), poly(d,l-lactide)-b-poly(ethylene glycol) (PLA-b-PEG), or poly(caprolactone)-b-poly(ethylene glycol) (PCL-b-PEG) were used as the stabilizer to prevent the nanoparticles from aggregation. The effect of the drug-to-stabilizer feed ratio on the particle stability were investigated. Moreover, the effect of the BCP composition on the morphology of Abm-loaded nanoparticles for controlling Meloidogyne incognita were discussed. Notably, spindle-like nanoparticles were obtained with PCL-b-PEG as the stabilizer and found significantly more efficient (98.4% mortality at 1 ppm particle concentration) than spherical nanoparticles using PLGA-b-PEG or PLA-b-PEG as the stabilizer. This work provides a more rapid and powerful method to prepare stable Abm-loaded nanoparticles with tunable morphologies and improved effectiveness for controlling Meloidogyne incognita. View Full-Text
Keywords: Meloidogyne incognita; Abamectin; flash nanoprecipitation; amphiphilic block copolymers; spindle-like nanoparticles Meloidogyne incognita; Abamectin; flash nanoprecipitation; amphiphilic block copolymers; spindle-like nanoparticles
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Fu, Z.; Chen, K.; Li, L.; Zhao, F.; Wang, Y.; Wang, M.; Shen, Y.; Cui, H.; Liu, D.; Guo, X. Spherical and Spindle-Like Abamectin-Loaded Nanoparticles by Flash Nanoprecipitation for Southern Root-Knot Nematode Control: Preparation and Characterization. Nanomaterials 2018, 8, 449.

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