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Nanomaterials 2018, 8(6), 384; https://doi.org/10.3390/nano8060384

Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer

1
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Korea
2
Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea
*
Author to whom correspondence should be addressed.
Received: 11 April 2018 / Revised: 11 May 2018 / Accepted: 30 May 2018 / Published: 31 May 2018
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Abstract

Resveratrol (RSV) and the ethanol extract of Angelica gigas Nakai (AGN Ex)-based nanoparticles (NPs) were prepared using the nanocrystal concept. AGN/RSV NPs with 224 nm hydrodynamic size, unimodal size distribution, and negative zeta potential values were developed with the emulsification and solvent evaporation techniques. The crystalline properties of AGN Ex and RSV were transformed during the emulsification and solvent evaporation processes, thus, AGN NPs and AGN/RSV NPs exhibited amorphous states. AGN/RSV NPs held up their initial hydrodynamic size after 24 h of incubation in serum-included media. Sustained release profiles (for 5 days) of decursin (D) and decursinol angelate (DA) (the representative markers of AGN Ex) and RSV were observed at normal physiological pH (pH 7.4). In ovarian cancer (SKOV-3) cells, although AGN/RSV NPs showed a lower cellular entry rate rather than AGN NPs, the cellular accumulated amount of AGN/RSV NPs was similar with that of AGN NPs after 4 h of incubation. The antiproliferation efficiency of AGN/RSV NPs group was significantly higher than the AGN Ex, AGN NPs, and AGN NPs + RSV groups in SKOV-3 cells. AGN/RSV NPs can be one of the promising candidates for therapeutic nanoplatforms against ovarian cancers. View Full-Text
Keywords: Angelica gigas Nakai; anticancer activities; nanocomposite; resveratrol; ovarian cancer Angelica gigas Nakai; anticancer activities; nanocomposite; resveratrol; ovarian cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Nam, S.; Lee, S.Y.; Kang, W.-S.; Cho, H.-J. Development of Resveratrol-Loaded Herbal Extract-Based Nanocomposites and Their Application to the Therapy of Ovarian Cancer. Nanomaterials 2018, 8, 384.

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