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Nanomaterials 2017, 7(9), 241; doi:10.3390/nano7090241

The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers

1
College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea
2
IN2BIO Research and Development center, Suwon 16681, Korea
3
Graduate School of Analytical Science and Technology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea
4
Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan 54538, Korea
*
Author to whom correspondence should be addressed.
Received: 1 August 2017 / Revised: 18 August 2017 / Accepted: 23 August 2017 / Published: 28 August 2017
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Abstract

Phenylethyl resorcinol (4-(1-phenylethyl)1,3-benzenediol) (PR) is a new whitening agent that has been found to have the ability to inhibit tyrosinase activity. However, the application of PR is limited by photo instability and poor solubility. PR-loaded nanostructured lipid carriers (PR-NLCs) were prepared by the hot-melted ultrasonic method. Glycerol monostearate and olive oil were selected as the solid lipid and liquid lipid for considering the solubility of PR in liquid lipid and partition coefficient of PR in solid lipid, respectively. The particle size and polydispersity index of PR-NLCs were 57.9 ± 1.3 nm and 0.24 ± 0.01, respectively. The encapsulation efficiency and loading capacity of PR-NLCs were 93.1 ± 4.2% and 8.5 ± 0.4%, respectively. The stability test demonstrated that the incorporation of PR into NLCs conferred excellent physicochemical stability and photo stability for at least three months at 4 °C in the dark and 25 °C under daylight. In vitro release of PR-NLCs revealed a sustained release pattern. Cellular tyrosinase assay showed that PR-NLCs could significantly inhibit tyrosinase activity in melanoma cells, suggesting that NLCs can be used as a biocompatible nanocarrier for the effective delivery of skin whitening agents. View Full-Text
Keywords: nanostructured lipid carriers; phenylethyl resorcinol; topical drug delivery; stability; cellular tyrosinase inhibition assay nanostructured lipid carriers; phenylethyl resorcinol; topical drug delivery; stability; cellular tyrosinase inhibition assay
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MDPI and ACS Style

Kim, B.-S.; Na, Y.-G.; Choi, J.-H.; Kim, I.; Lee, E.; Kim, S.-Y.; Lee, J.-Y.; Cho, C.-W. The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers. Nanomaterials 2017, 7, 241.

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