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Nanomaterials 2017, 7(4), 85;

Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle

Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33305, Taiwan
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
These authors contributed equally to this paper.
Author to whom correspondence should be addressed.
Academic Editor: Yurii K. Gun’ko
Received: 14 March 2017 / Revised: 30 March 2017 / Accepted: 7 April 2017 / Published: 13 April 2017
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In clinical tumor therapy, chemotherapeutic routes have caused severe side effects; current delivery methods are unsatisfactory. Successful design of a remotely folate (FA)-grafted chitosan (CS)-coated magnetic nanoparticle (MNP) with low toxicity, has been achieved. A chemotherapeutic drug such as doxorubicin (DOX), is loaded in the MNP-based matrix (FA-grafted CS-DOX-TPP-MNP), which is coated by an activated target tumor molecule of FA-grafted CS biopolymer with the inclusion of tripolyphosphate (TPP) as a linker. The resultant nano-complexes exhibited random aggregates (~240 nm) and zeta potential (−24.9 mV). In vivo experiments using athymic BALB/c nude mice with human glioblastoma U87 cells in a subcutaneous tumor model revealed that magnetic guidance of FA-grafted CS-DOX-TPP-MNP, injected via the tail vein, significantly decreased tumor growth. This manuscript demonstrates the feasibility of magnetizing control of FA-grafted CS-DOX-TPP-MNP to enhance the localization of drug release. View Full-Text
Keywords: magnetic nanoparticles; doxorubicin; chitosan; remote delivery; antitumor effect magnetic nanoparticles; doxorubicin; chitosan; remote delivery; antitumor effect

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, C.-L.; Chen, J.-P.; Wei, K.-C.; Chen, J.-Y.; Huang, C.-W.; Liao, Z.-X. Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle. Nanomaterials 2017, 7, 85.

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