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Nanomaterials 2017, 7(4), 85; doi:10.3390/nano7040085

Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle

1
Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
2
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33305, Taiwan
3
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
These authors contributed equally to this paper.
*
Author to whom correspondence should be addressed.
Academic Editor: Yurii K. Gun’ko
Received: 14 March 2017 / Revised: 30 March 2017 / Accepted: 7 April 2017 / Published: 13 April 2017
View Full-Text   |   Download PDF [3441 KB, uploaded 13 April 2017]   |  

Abstract

In clinical tumor therapy, chemotherapeutic routes have caused severe side effects; current delivery methods are unsatisfactory. Successful design of a remotely folate (FA)-grafted chitosan (CS)-coated magnetic nanoparticle (MNP) with low toxicity, has been achieved. A chemotherapeutic drug such as doxorubicin (DOX), is loaded in the MNP-based matrix (FA-grafted CS-DOX-TPP-MNP), which is coated by an activated target tumor molecule of FA-grafted CS biopolymer with the inclusion of tripolyphosphate (TPP) as a linker. The resultant nano-complexes exhibited random aggregates (~240 nm) and zeta potential (−24.9 mV). In vivo experiments using athymic BALB/c nude mice with human glioblastoma U87 cells in a subcutaneous tumor model revealed that magnetic guidance of FA-grafted CS-DOX-TPP-MNP, injected via the tail vein, significantly decreased tumor growth. This manuscript demonstrates the feasibility of magnetizing control of FA-grafted CS-DOX-TPP-MNP to enhance the localization of drug release. View Full-Text
Keywords: magnetic nanoparticles; doxorubicin; chitosan; remote delivery; antitumor effect magnetic nanoparticles; doxorubicin; chitosan; remote delivery; antitumor effect
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MDPI and ACS Style

Yang, C.-L.; Chen, J.-P.; Wei, K.-C.; Chen, J.-Y.; Huang, C.-W.; Liao, Z.-X. Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle. Nanomaterials 2017, 7, 85.

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