Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle
AbstractIn clinical tumor therapy, chemotherapeutic routes have caused severe side effects; current delivery methods are unsatisfactory. Successful design of a remotely folate (FA)-grafted chitosan (CS)-coated magnetic nanoparticle (MNP) with low toxicity, has been achieved. A chemotherapeutic drug such as doxorubicin (DOX), is loaded in the MNP-based matrix (FA-grafted CS-DOX-TPP-MNP), which is coated by an activated target tumor molecule of FA-grafted CS biopolymer with the inclusion of tripolyphosphate (TPP) as a linker. The resultant nano-complexes exhibited random aggregates (~240 nm) and zeta potential (−24.9 mV). In vivo experiments using athymic BALB/c nude mice with human glioblastoma U87 cells in a subcutaneous tumor model revealed that magnetic guidance of FA-grafted CS-DOX-TPP-MNP, injected via the tail vein, significantly decreased tumor growth. This manuscript demonstrates the feasibility of magnetizing control of FA-grafted CS-DOX-TPP-MNP to enhance the localization of drug release. View Full-Text
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Yang, C.-L.; Chen, J.-P.; Wei, K.-C.; Chen, J.-Y.; Huang, C.-W.; Liao, Z.-X. Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle. Nanomaterials 2017, 7, 85.
Yang C-L, Chen J-P, Wei K-C, Chen J-Y, Huang C-W, Liao Z-X. Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle. Nanomaterials. 2017; 7(4):85.Chicago/Turabian Style
Yang, Chung-Lin; Chen, Jyh-Ping; Wei, Kuo-Chen; Chen, Ju-Yu; Huang, Chia-Wen; Liao, Zi-Xian. 2017. "Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle." Nanomaterials 7, no. 4: 85.
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