Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging
Abstract
:1. Introduction
2. Results and Discussion
2.1. Materials Preparation and Characterization
2.2. Relaxivity Measurements and In Vitro MRI
2.3. Cytotoxicity Test
2.4. In Vivo MRI Studies Imaging
3. Experimental Section
3.1. Materials
3.2. Synthesis of Gd(H2O)4[Fe(CN)6]
3.3. Synthesis of GdSi Oxide/hydroxide Nanocomposite
3.4. Materials Characterization
3.5. Stability Assays
3.6. Cell Biocompatibility
3.7. 1H NMR Relaxometry Study and In Vitro MRI.
3.8. In Vivo MRI Studies Imaging
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Sample | Molecular Formula | Atomic Composition (%) a | Size (nm) | Area BET (m2·g−1) b | |||
---|---|---|---|---|---|---|---|
Gd | Fe | Si | TEM c | DLS d | |||
GdFe | Gd(H2O)4[Fe(CN)6] | 52.8 | 47.2 | -- | 94.2 ± 35.5 | nd e | nd e |
GdSi | Gd(OH)3·3SiO2·xH2O | 18.6 | 1.3 | 80.1 | 75.2 ± 24.0 | 84 ± 44 | 19.0 |
Sample | r1/s−1·mM−1 | r2/s−1·mM−1 | r2/r1 |
---|---|---|---|
GdSi | 5.6 | 8.2 | 1.4 |
Gd-DTPA | 4.1 | 3.3 | 0.8 |
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Cabrera-García, A.; Vidal-Moya, A.; Bernabeu, Á.; Pacheco-Torres, J.; Checa-Chavarria, E.; Fernández, E.; Botella, P. Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging. Nanomaterials 2016, 6, 109. https://doi.org/10.3390/nano6060109
Cabrera-García A, Vidal-Moya A, Bernabeu Á, Pacheco-Torres J, Checa-Chavarria E, Fernández E, Botella P. Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging. Nanomaterials. 2016; 6(6):109. https://doi.org/10.3390/nano6060109
Chicago/Turabian StyleCabrera-García, Alejandro, Alejandro Vidal-Moya, Ángela Bernabeu, Jesús Pacheco-Torres, Elisa Checa-Chavarria, Eduardo Fernández, and Pablo Botella. 2016. "Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging" Nanomaterials 6, no. 6: 109. https://doi.org/10.3390/nano6060109