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Nanomaterials 2016, 6(6), 109;

Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging

Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, Spain
Unit of Magnetic Resonance Imaging, Hospital Universitario de Alicante, INSCANNER S.L., Alicante, Spain
Unit of Functional Magnetic Resonance Imaging, Instituto de Neurociencias (CSIC-UMH), Alicante, Spain
Institute of Bioengineering, Universidad Miguel Hernández, Elche, Spain and Centre for Network Biomedical Research (CIBER-BBN), Spain
Author to whom correspondence should be addressed.
Academic Editors: Eva Pellicer and Jordi Sort Viñas
Received: 29 March 2016 / Revised: 6 May 2016 / Accepted: 27 May 2016 / Published: 8 June 2016
(This article belongs to the Special Issue Nanomaterials for Cancer Therapies)
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We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type of magnetic nanoparticle based on Gd-Si oxide, which presents high Gd3+ atom density. For this purpose, we have used a Prussian Blue analogue as the sacrificial template by reacting with soluble silicate, obtaining particles with nanorod morphology and of small size (75 nm). These nanoparticles present good biocompatibility and higher longitudinal and transversal relaxivity values than commercial Gd3+ solutions, which significantly improves the sensitivity of in vivo magnetic resonance images. View Full-Text
Keywords: Prussian Blue analogues; Gd-Si nanoparticles; magnetic resonance imaging; contrast agent Prussian Blue analogues; Gd-Si nanoparticles; magnetic resonance imaging; contrast agent

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Cabrera-García, A.; Vidal-Moya, A.; Bernabeu, Á.; Pacheco-Torres, J.; Checa-Chavarria, E.; Fernández, E.; Botella, P. Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging. Nanomaterials 2016, 6, 109.

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