Next Article in Journal
Erratum: Mustafa, R.; Luo, Y.; Wu, Y.; Guo, R.; Shi, X. Dendrimer-Functionalized Laponite® Nanodisks as a Platform for Anticancer Drug Delivery. Nanomaterials 2015, 5, 1716–1731
Next Article in Special Issue
Targeting and Photodynamic Killing of Cancer Cell by Nitrogen-Doped Titanium Dioxide Coupled with Folic Acid
Previous Article in Journal
A Flexible 360-Degree Thermal Sound Source Based on Laser Induced Graphene
Previous Article in Special Issue
PDE5 Inhibitors-Loaded Nanovesicles: Physico-Chemical Properties and In Vitro Antiproliferative Activity
Article Menu

Export Article

Open AccessFeature PaperArticle
Nanomaterials 2016, 6(6), 109; doi:10.3390/nano6060109

Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging

1
Instituto de Tecnología Química, Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avenida de los Naranjos s/n, 46022 Valencia, Spain
2
Unit of Magnetic Resonance Imaging, Hospital Universitario de Alicante, INSCANNER S.L., Alicante, Spain
3
Unit of Functional Magnetic Resonance Imaging, Instituto de Neurociencias (CSIC-UMH), Alicante, Spain
4
Institute of Bioengineering, Universidad Miguel Hernández, Elche, Spain and Centre for Network Biomedical Research (CIBER-BBN), Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Eva Pellicer and Jordi Sort Viñas
Received: 29 March 2016 / Revised: 6 May 2016 / Accepted: 27 May 2016 / Published: 8 June 2016
(This article belongs to the Special Issue Nanomaterials for Cancer Therapies)
View Full-Text   |   Download PDF [4611 KB, uploaded 8 June 2016]   |  

Abstract

We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type of magnetic nanoparticle based on Gd-Si oxide, which presents high Gd3+ atom density. For this purpose, we have used a Prussian Blue analogue as the sacrificial template by reacting with soluble silicate, obtaining particles with nanorod morphology and of small size (75 nm). These nanoparticles present good biocompatibility and higher longitudinal and transversal relaxivity values than commercial Gd3+ solutions, which significantly improves the sensitivity of in vivo magnetic resonance images. View Full-Text
Keywords: Prussian Blue analogues; Gd-Si nanoparticles; magnetic resonance imaging; contrast agent Prussian Blue analogues; Gd-Si nanoparticles; magnetic resonance imaging; contrast agent
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cabrera-García, A.; Vidal-Moya, A.; Bernabeu, Á.; Pacheco-Torres, J.; Checa-Chavarria, E.; Fernández, E.; Botella, P. Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging. Nanomaterials 2016, 6, 109.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top