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Nanomaterials 2015, 5(1), 246-267;

DNA under Force: Mechanics, Electrostatics, and Hydration

Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA
Department of Physics, George Washington University, Washington, DC 20052, USA
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Authors to whom correspondence should be addressed.
Academic Editor: Stephen Ralph
Received: 9 December 2014 / Revised: 16 January 2015 / Accepted: 12 February 2015 / Published: 25 February 2015
(This article belongs to the Special Issue Frontiers in Nucleic Acid Nanotechnology)
View Full-Text   |   Download PDF [1633 KB, uploaded 25 February 2015]   |  


Quantifying the basic intra- and inter-molecular forces of DNA has helped us to better understand and further predict the behavior of DNA. Single molecule technique elucidates the mechanics of DNA under applied external forces, sometimes under extreme forces. On the other hand, ensemble studies of DNA molecular force allow us to extend our understanding of DNA molecules under other forces such as electrostatic and hydration forces. Using a variety of techniques, we can have a comprehensive understanding of DNA molecular forces, which is crucial in unraveling the complex DNA functions in living cells as well as in designing a system that utilizes the unique properties of DNA in nanotechnology. View Full-Text
Keywords: DNA; mechanics; electrostatics; hydration DNA; mechanics; electrostatics; hydration

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Li, J.; Wijeratne, S.S.; Qiu, X.; Kiang, C.-H. DNA under Force: Mechanics, Electrostatics, and Hydration. Nanomaterials 2015, 5, 246-267.

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