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J. Funct. Biomater. 2018, 9(2), 33; https://doi.org/10.3390/jfb9020033

Synthesis and Characterization of Injectable Hydrogels with Varying Collagen–Chitosan–Thymosin β4 Composition for Myocardial Infarction Therapy

1
Biomedical Engineering Study Program, Department of Physics, Faculty of Science and Technology, Airlangga University, Surabaya 60115, East Java, Indonesia
2
Institute of Tropical Disease, Airlangga University, Surabaya 60115, East Java, Indonesia
3
Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya 60286, East Java, Indonesia
*
Author to whom correspondence should be addressed.
Received: 24 December 2017 / Revised: 8 March 2018 / Accepted: 9 March 2018 / Published: 30 April 2018
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Abstract

Thirty percent of global mortalities are caused by cardiovascular disease, and 54% of the aforementioned amount is instigated by ischemic heart disease that triggered myocardial infarction. Myocardial infarction is due to blood flow cessation in certain coronary arteries that causes lack of oxygen (ischemia) and stimulates myocardial necrosis. One of the methods to treat myocardial infarction consists in injecting cells or active biomolecules and biomaterials into heart infarction locations. This study aimed to investigate the characteristics of a collagen–chitosan-based hydrogel with variations in its chitosan composition. The prepared hydrogels contained thymosin β4 (Tβ4), a 43-amino acid peptide with angiogenic and cardioprotective properties which can act as a bioactive molecule for the treatment of myocardial infarction. A morphological structure analysis showed that the hydrogels lacked interconnecting pores. All samples were not toxic on the basis of a cytotoxicity test. A histopathological anatomy test showed that the collagen–chitosan–thymosin β4 hydrogels could stimulate angiogenesis and epicardial heart cell migration, as demonstrated by the evaluation of the number of blood vessels and the infiltration extent of myofibroblasts. View Full-Text
Keywords: myocardial infarction; hydrogel; collagen; chitosan; thymosin β4 myocardial infarction; hydrogel; collagen; chitosan; thymosin β4
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Shaghiera, A.D.; Widiyanti, P.; Yusuf, H. Synthesis and Characterization of Injectable Hydrogels with Varying Collagen–Chitosan–Thymosin β4 Composition for Myocardial Infarction Therapy. J. Funct. Biomater. 2018, 9, 33.

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